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Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series
Mycophenolate mofetil (MMF) is an immunosuppressive medication utilized in the management of both autoimmune and solid organ transplant patients. Diarrhea is a common gastrointestinal side effect of MMF, but more severe forms of GI symptoms are described in renal transplant patients with a distinct...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485763/ https://www.ncbi.nlm.nih.gov/pubmed/23133776 http://dx.doi.org/10.1155/2012/624168 |
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author | Dykes, Dana M. H. Moore, Sean R. Polk, D. Brent Rosen, Michael J. Wills, Marcia L. Morris, Brian Maclin, Jeanine S. Nogueira, Janaina Katz, Avi Hunley, Tracey E. Pugh, Judith Saeed, Shehzad |
author_facet | Dykes, Dana M. H. Moore, Sean R. Polk, D. Brent Rosen, Michael J. Wills, Marcia L. Morris, Brian Maclin, Jeanine S. Nogueira, Janaina Katz, Avi Hunley, Tracey E. Pugh, Judith Saeed, Shehzad |
author_sort | Dykes, Dana M. H. |
collection | PubMed |
description | Mycophenolate mofetil (MMF) is an immunosuppressive medication utilized in the management of both autoimmune and solid organ transplant patients. Diarrhea is a common gastrointestinal side effect of MMF, but more severe forms of GI symptoms are described in renal transplant patients with a distinct pattern of histopathologic change, similar to graft-versus-host disease or Crohn's disease. This rare entity, commonly referred to as “MMF-related enterocolitis,” has been described in adult patients, mostly in renal transplant patients, and in only two pediatric renal transplant patients. In previously reported cases, symptoms and abnormal histopathology improve with dose reduction of MMF. We describe a series of three pediatric patients with varied underlying disease process who presented with severe diarrhea and histopathologic findings characteristic of MMF-related enterocolitis, who share a novel finding of weight loss as a complication of MMF-related enterocolitis in pediatric patients. |
format | Online Article Text |
id | pubmed-3485763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34857632012-11-06 Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series Dykes, Dana M. H. Moore, Sean R. Polk, D. Brent Rosen, Michael J. Wills, Marcia L. Morris, Brian Maclin, Jeanine S. Nogueira, Janaina Katz, Avi Hunley, Tracey E. Pugh, Judith Saeed, Shehzad Case Rep Pediatr Case Report Mycophenolate mofetil (MMF) is an immunosuppressive medication utilized in the management of both autoimmune and solid organ transplant patients. Diarrhea is a common gastrointestinal side effect of MMF, but more severe forms of GI symptoms are described in renal transplant patients with a distinct pattern of histopathologic change, similar to graft-versus-host disease or Crohn's disease. This rare entity, commonly referred to as “MMF-related enterocolitis,” has been described in adult patients, mostly in renal transplant patients, and in only two pediatric renal transplant patients. In previously reported cases, symptoms and abnormal histopathology improve with dose reduction of MMF. We describe a series of three pediatric patients with varied underlying disease process who presented with severe diarrhea and histopathologic findings characteristic of MMF-related enterocolitis, who share a novel finding of weight loss as a complication of MMF-related enterocolitis in pediatric patients. Hindawi Publishing Corporation 2012 2012-10-23 /pmc/articles/PMC3485763/ /pubmed/23133776 http://dx.doi.org/10.1155/2012/624168 Text en Copyright © 2012 Dana M. H. Dykes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Dykes, Dana M. H. Moore, Sean R. Polk, D. Brent Rosen, Michael J. Wills, Marcia L. Morris, Brian Maclin, Jeanine S. Nogueira, Janaina Katz, Avi Hunley, Tracey E. Pugh, Judith Saeed, Shehzad Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series |
title | Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series |
title_full | Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series |
title_fullStr | Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series |
title_full_unstemmed | Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series |
title_short | Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series |
title_sort | mycophenolate mofetil-related enterocolitis and weight loss: a pediatric case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485763/ https://www.ncbi.nlm.nih.gov/pubmed/23133776 http://dx.doi.org/10.1155/2012/624168 |
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