Cargando…
The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We sea...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485862/ https://www.ncbi.nlm.nih.gov/pubmed/23133749 http://dx.doi.org/10.1155/2012/493219 |
_version_ | 1782248363209523200 |
---|---|
author | Tayebi, Sirous Mohamadkhani, Ashraf |
author_facet | Tayebi, Sirous Mohamadkhani, Ashraf |
author_sort | Tayebi, Sirous |
collection | PubMed |
description | Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association. |
format | Online Article Text |
id | pubmed-3485862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34858622012-11-06 The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection Tayebi, Sirous Mohamadkhani, Ashraf Hepat Res Treat Review Article Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3485862/ /pubmed/23133749 http://dx.doi.org/10.1155/2012/493219 Text en Copyright © 2012 S. Tayebi and A. Mohamadkhani. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tayebi, Sirous Mohamadkhani, Ashraf The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection |
title | The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection |
title_full | The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection |
title_fullStr | The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection |
title_full_unstemmed | The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection |
title_short | The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection |
title_sort | tnf-α -308 promoter gene polymorphism and chronic hbv infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485862/ https://www.ncbi.nlm.nih.gov/pubmed/23133749 http://dx.doi.org/10.1155/2012/493219 |
work_keys_str_mv | AT tayebisirous thetnfa308promotergenepolymorphismandchronichbvinfection AT mohamadkhaniashraf thetnfa308promotergenepolymorphismandchronichbvinfection AT tayebisirous tnfa308promotergenepolymorphismandchronichbvinfection AT mohamadkhaniashraf tnfa308promotergenepolymorphismandchronichbvinfection |