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The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection

Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We sea...

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Detalles Bibliográficos
Autores principales: Tayebi, Sirous, Mohamadkhani, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485862/
https://www.ncbi.nlm.nih.gov/pubmed/23133749
http://dx.doi.org/10.1155/2012/493219
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author Tayebi, Sirous
Mohamadkhani, Ashraf
author_facet Tayebi, Sirous
Mohamadkhani, Ashraf
author_sort Tayebi, Sirous
collection PubMed
description Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association.
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spelling pubmed-34858622012-11-06 The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection Tayebi, Sirous Mohamadkhani, Ashraf Hepat Res Treat Review Article Background and Aims. TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection. We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection. Methods. We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”. We only focused on searching -308 locus in published studies. We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results. Results. conflicting results were observed. The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection. We summarized the primary data as a table. Conclusions. Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3485862/ /pubmed/23133749 http://dx.doi.org/10.1155/2012/493219 Text en Copyright © 2012 S. Tayebi and A. Mohamadkhani. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tayebi, Sirous
Mohamadkhani, Ashraf
The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
title The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
title_full The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
title_fullStr The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
title_full_unstemmed The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
title_short The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
title_sort tnf-α -308 promoter gene polymorphism and chronic hbv infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485862/
https://www.ncbi.nlm.nih.gov/pubmed/23133749
http://dx.doi.org/10.1155/2012/493219
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