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Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians

Introduction. Appropriate use of genetic tests for population-based cancer screening, diagnosis of inherited cancers, and guidance of cancer treatment can improve health outcomes. We investigated clinicians' use and knowledge of eight breast, ovarian, and colorectal cancer genetic tests. Method...

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Autores principales: Cox, Summer L., Zlot, Amy I., Silvey, Kerry, Elliott, Debi, Horn, Tara, Johnson, Amber, Leman, Richard F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485974/
https://www.ncbi.nlm.nih.gov/pubmed/23150730
http://dx.doi.org/10.1155/2012/294730
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author Cox, Summer L.
Zlot, Amy I.
Silvey, Kerry
Elliott, Debi
Horn, Tara
Johnson, Amber
Leman, Richard F.
author_facet Cox, Summer L.
Zlot, Amy I.
Silvey, Kerry
Elliott, Debi
Horn, Tara
Johnson, Amber
Leman, Richard F.
author_sort Cox, Summer L.
collection PubMed
description Introduction. Appropriate use of genetic tests for population-based cancer screening, diagnosis of inherited cancers, and guidance of cancer treatment can improve health outcomes. We investigated clinicians' use and knowledge of eight breast, ovarian, and colorectal cancer genetic tests. Methods. We conducted a randomized survey of 2,191 Oregon providers, asking about their experience with fecal DNA, OncoVue, BRCA, MMR, CYP2D6, tumor gene expression profiling, UGT1A1, and KRAS. Results. Clinicians reported low confidence in their knowledge of medical genetics; most confident were OB-GYNs and specialists. Clinicians were more likely to have ordered/recommended BRCA and MMR than the other tests, and OB-GYNs were twice as likely to have ordered/recommended BRCA testing than primary care providers. Less than 10% of providers ordered/recommended OncoVue, fecal DNA, CYP2D6, or UGT1A1; less than 30% ordered/recommended tumor gene expression profiles or KRAS. The most common reason for not ordering/recommending these tests was lack of familiarity. Conclusions. Use of appropriate, evidence-based testing can help reduce incidence and mortality of certain cancers, but these tests need to be better integrated into clinical practice. Continued evaluation of emerging technologies, dissemination of findings, and an increase in provider confidence and knowledge are necessary to achieve this end.
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spelling pubmed-34859742012-11-13 Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians Cox, Summer L. Zlot, Amy I. Silvey, Kerry Elliott, Debi Horn, Tara Johnson, Amber Leman, Richard F. J Cancer Epidemiol Research Article Introduction. Appropriate use of genetic tests for population-based cancer screening, diagnosis of inherited cancers, and guidance of cancer treatment can improve health outcomes. We investigated clinicians' use and knowledge of eight breast, ovarian, and colorectal cancer genetic tests. Methods. We conducted a randomized survey of 2,191 Oregon providers, asking about their experience with fecal DNA, OncoVue, BRCA, MMR, CYP2D6, tumor gene expression profiling, UGT1A1, and KRAS. Results. Clinicians reported low confidence in their knowledge of medical genetics; most confident were OB-GYNs and specialists. Clinicians were more likely to have ordered/recommended BRCA and MMR than the other tests, and OB-GYNs were twice as likely to have ordered/recommended BRCA testing than primary care providers. Less than 10% of providers ordered/recommended OncoVue, fecal DNA, CYP2D6, or UGT1A1; less than 30% ordered/recommended tumor gene expression profiles or KRAS. The most common reason for not ordering/recommending these tests was lack of familiarity. Conclusions. Use of appropriate, evidence-based testing can help reduce incidence and mortality of certain cancers, but these tests need to be better integrated into clinical practice. Continued evaluation of emerging technologies, dissemination of findings, and an increase in provider confidence and knowledge are necessary to achieve this end. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3485974/ /pubmed/23150730 http://dx.doi.org/10.1155/2012/294730 Text en Copyright © 2012 Summer L. Cox et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cox, Summer L.
Zlot, Amy I.
Silvey, Kerry
Elliott, Debi
Horn, Tara
Johnson, Amber
Leman, Richard F.
Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians
title Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians
title_full Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians
title_fullStr Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians
title_full_unstemmed Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians
title_short Patterns of Cancer Genetic Testing: A Randomized Survey of Oregon Clinicians
title_sort patterns of cancer genetic testing: a randomized survey of oregon clinicians
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485974/
https://www.ncbi.nlm.nih.gov/pubmed/23150730
http://dx.doi.org/10.1155/2012/294730
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