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Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla

AIMS: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). MATE...

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Autores principales: Uda, T., Takami, T., Sakamoto, S., Tsuyuguchi, N., Yamagata, T., Ohata, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486000/
https://www.ncbi.nlm.nih.gov/pubmed/23125493
http://dx.doi.org/10.4103/0974-8237.100060
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author Uda, T.
Takami, T.
Sakamoto, S.
Tsuyuguchi, N.
Yamagata, T.
Ohata, K.
author_facet Uda, T.
Takami, T.
Sakamoto, S.
Tsuyuguchi, N.
Yamagata, T.
Ohata, K.
author_sort Uda, T.
collection PubMed
description AIMS: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). MATERIALS AND METHODS: Thirty healthy subjects (mean age = 44.2 years, range = 20–72 years) were enrolled for this study. Mean values of MD and FA in six spinal levels (C2/3, C3/4, C4/5, C5/6, C6/7, and C7/Th1) were measured. Mean values, variances, and distributions of the MD and FA in each spinal level were analyzed. Age-dependent change of MD and FA as well as correlation between MD and FA was also analyzed. RESULTS: At all spinal levels, the values can be considered to be Gaussian distribution in MD but not in FA. A significant statistical negative correlation was observed between aging and the values of MD (r = 0.429, P = 0.018), but insignificant between the values of FA (P = 0.234). A slight significant statistical negative correlation was observed between the values of MD and FA (r = 0.156, P = 0.037). One way repeated measures analysis of variance indicated the significant difference between the spinal levels in both MD (P = 0.003) and FA (P < 0.0001). CONCLUSIONS: The analyzed data in the present study would be helpful for comparison when investigating the spinal condition of spinal disorders.
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spelling pubmed-34860002012-11-02 Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla Uda, T. Takami, T. Sakamoto, S. Tsuyuguchi, N. Yamagata, T. Ohata, K. J Craniovertebr Junction Spine Original Article AIMS: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). MATERIALS AND METHODS: Thirty healthy subjects (mean age = 44.2 years, range = 20–72 years) were enrolled for this study. Mean values of MD and FA in six spinal levels (C2/3, C3/4, C4/5, C5/6, C6/7, and C7/Th1) were measured. Mean values, variances, and distributions of the MD and FA in each spinal level were analyzed. Age-dependent change of MD and FA as well as correlation between MD and FA was also analyzed. RESULTS: At all spinal levels, the values can be considered to be Gaussian distribution in MD but not in FA. A significant statistical negative correlation was observed between aging and the values of MD (r = 0.429, P = 0.018), but insignificant between the values of FA (P = 0.234). A slight significant statistical negative correlation was observed between the values of MD and FA (r = 0.156, P = 0.037). One way repeated measures analysis of variance indicated the significant difference between the spinal levels in both MD (P = 0.003) and FA (P < 0.0001). CONCLUSIONS: The analyzed data in the present study would be helpful for comparison when investigating the spinal condition of spinal disorders. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3486000/ /pubmed/23125493 http://dx.doi.org/10.4103/0974-8237.100060 Text en Copyright: © Journal of Craniovertebral Junction and Spine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Uda, T.
Takami, T.
Sakamoto, S.
Tsuyuguchi, N.
Yamagata, T.
Ohata, K.
Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
title Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
title_full Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
title_fullStr Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
title_full_unstemmed Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
title_short Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
title_sort normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-tesla
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486000/
https://www.ncbi.nlm.nih.gov/pubmed/23125493
http://dx.doi.org/10.4103/0974-8237.100060
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