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Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla
AIMS: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). MATE...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486000/ https://www.ncbi.nlm.nih.gov/pubmed/23125493 http://dx.doi.org/10.4103/0974-8237.100060 |
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author | Uda, T. Takami, T. Sakamoto, S. Tsuyuguchi, N. Yamagata, T. Ohata, K. |
author_facet | Uda, T. Takami, T. Sakamoto, S. Tsuyuguchi, N. Yamagata, T. Ohata, K. |
author_sort | Uda, T. |
collection | PubMed |
description | AIMS: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). MATERIALS AND METHODS: Thirty healthy subjects (mean age = 44.2 years, range = 20–72 years) were enrolled for this study. Mean values of MD and FA in six spinal levels (C2/3, C3/4, C4/5, C5/6, C6/7, and C7/Th1) were measured. Mean values, variances, and distributions of the MD and FA in each spinal level were analyzed. Age-dependent change of MD and FA as well as correlation between MD and FA was also analyzed. RESULTS: At all spinal levels, the values can be considered to be Gaussian distribution in MD but not in FA. A significant statistical negative correlation was observed between aging and the values of MD (r = 0.429, P = 0.018), but insignificant between the values of FA (P = 0.234). A slight significant statistical negative correlation was observed between the values of MD and FA (r = 0.156, P = 0.037). One way repeated measures analysis of variance indicated the significant difference between the spinal levels in both MD (P = 0.003) and FA (P < 0.0001). CONCLUSIONS: The analyzed data in the present study would be helpful for comparison when investigating the spinal condition of spinal disorders. |
format | Online Article Text |
id | pubmed-3486000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34860002012-11-02 Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla Uda, T. Takami, T. Sakamoto, S. Tsuyuguchi, N. Yamagata, T. Ohata, K. J Craniovertebr Junction Spine Original Article AIMS: The purposes of the present study were to clarify the normal variation and to determine the normal reference values of diffusion tensor (DT) parameters (mean diffusivity [MD] and fractional anisotropy [FA]) of the spinal cord in single-shot fast spin-echo-based sequence at 3.0-Tesla (3T). MATERIALS AND METHODS: Thirty healthy subjects (mean age = 44.2 years, range = 20–72 years) were enrolled for this study. Mean values of MD and FA in six spinal levels (C2/3, C3/4, C4/5, C5/6, C6/7, and C7/Th1) were measured. Mean values, variances, and distributions of the MD and FA in each spinal level were analyzed. Age-dependent change of MD and FA as well as correlation between MD and FA was also analyzed. RESULTS: At all spinal levels, the values can be considered to be Gaussian distribution in MD but not in FA. A significant statistical negative correlation was observed between aging and the values of MD (r = 0.429, P = 0.018), but insignificant between the values of FA (P = 0.234). A slight significant statistical negative correlation was observed between the values of MD and FA (r = 0.156, P = 0.037). One way repeated measures analysis of variance indicated the significant difference between the spinal levels in both MD (P = 0.003) and FA (P < 0.0001). CONCLUSIONS: The analyzed data in the present study would be helpful for comparison when investigating the spinal condition of spinal disorders. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3486000/ /pubmed/23125493 http://dx.doi.org/10.4103/0974-8237.100060 Text en Copyright: © Journal of Craniovertebral Junction and Spine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Uda, T. Takami, T. Sakamoto, S. Tsuyuguchi, N. Yamagata, T. Ohata, K. Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla |
title | Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla |
title_full | Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla |
title_fullStr | Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla |
title_full_unstemmed | Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla |
title_short | Normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-Tesla |
title_sort | normal variation of diffusion tensor parameters of the spinal cord in healthy subjects at 3.0-tesla |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486000/ https://www.ncbi.nlm.nih.gov/pubmed/23125493 http://dx.doi.org/10.4103/0974-8237.100060 |
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