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Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells

Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetal β-cell is unknown. We measured the impact of one wee...

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Detalles Bibliográficos
Autores principales:	Frost, Mackenzie S., Zehri, Aqib H., Limesand, Sean W., Hay, William W., Rozance, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486011/ https://www.ncbi.nlm.nih.gov/pubmed/23133755 http://dx.doi.org/10.1155/2012/812094

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