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Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale
The motor examination section of the unified Parkinson's disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 193 persons enrolled in a population-based study in Cent...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486132/ https://www.ncbi.nlm.nih.gov/pubmed/23133789 http://dx.doi.org/10.1155/2012/719167 |
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author | Vassar, Stefanie D. Bordelon, Yvette M. Hays, Ron D. Diaz, Natalie Rausch, Rebecca Mao, Cherry Vickrey, Barbara G. |
author_facet | Vassar, Stefanie D. Bordelon, Yvette M. Hays, Ron D. Diaz, Natalie Rausch, Rebecca Mao, Cherry Vickrey, Barbara G. |
author_sort | Vassar, Stefanie D. |
collection | PubMed |
description | The motor examination section of the unified Parkinson's disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 193 persons enrolled in a population-based study in Central California. Patients were examined after overnight PD medication washout (“OFF” state) and approximately one hour after taking medication (“ON” state). We performed confirmatory factor analysis of the UPDRS for OFF and ON state examinations; correlations, reliability, and relative validity of resulting subscales were evaluated. A model with five factors (gait/posture, tremor, rigidity, bradykinesia affecting the left extremities, bradykinesia affecting the right extremities) fit the data well, with similar results for OFF and ON states. Internal consistency reliability coefficients were 0.90 or higher for all subscales. The gait/posture subscale most strongly discriminated across levels of patient reported PD symptom severity and of how PD affects them on a daily basis. Compared to the right sided bradykinesia subscale, the left sided bradykinesia subscale had higher discrimination across levels of self-reported PD symptom severity and functional impairment. This supports motor UPDRS containing multiple subscales that can be analyzed separately and provide information distinct from the total score that may be useful in clinical studies. |
format | Online Article Text |
id | pubmed-3486132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34861322012-11-06 Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale Vassar, Stefanie D. Bordelon, Yvette M. Hays, Ron D. Diaz, Natalie Rausch, Rebecca Mao, Cherry Vickrey, Barbara G. Parkinsons Dis Research Article The motor examination section of the unified Parkinson's disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 193 persons enrolled in a population-based study in Central California. Patients were examined after overnight PD medication washout (“OFF” state) and approximately one hour after taking medication (“ON” state). We performed confirmatory factor analysis of the UPDRS for OFF and ON state examinations; correlations, reliability, and relative validity of resulting subscales were evaluated. A model with five factors (gait/posture, tremor, rigidity, bradykinesia affecting the left extremities, bradykinesia affecting the right extremities) fit the data well, with similar results for OFF and ON states. Internal consistency reliability coefficients were 0.90 or higher for all subscales. The gait/posture subscale most strongly discriminated across levels of patient reported PD symptom severity and of how PD affects them on a daily basis. Compared to the right sided bradykinesia subscale, the left sided bradykinesia subscale had higher discrimination across levels of self-reported PD symptom severity and functional impairment. This supports motor UPDRS containing multiple subscales that can be analyzed separately and provide information distinct from the total score that may be useful in clinical studies. Hindawi Publishing Corporation 2012 2012-10-22 /pmc/articles/PMC3486132/ /pubmed/23133789 http://dx.doi.org/10.1155/2012/719167 Text en Copyright © 2012 Stefanie D. Vassar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vassar, Stefanie D. Bordelon, Yvette M. Hays, Ron D. Diaz, Natalie Rausch, Rebecca Mao, Cherry Vickrey, Barbara G. Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale |
title | Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale |
title_full | Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale |
title_fullStr | Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale |
title_full_unstemmed | Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale |
title_short | Confirmatory Factor Analysis of the Motor Unified Parkinson's Disease Rating Scale |
title_sort | confirmatory factor analysis of the motor unified parkinson's disease rating scale |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486132/ https://www.ncbi.nlm.nih.gov/pubmed/23133789 http://dx.doi.org/10.1155/2012/719167 |
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