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The β(1)-Subunit of Na(v)1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction

Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy. Several mutations on the cardiac sodium channel Na(v)1.5 which are responsible for BrS lead to misfolded proteins that do not traffic properly to the plasma membrane. In order to mimic patient heterozygosity, a traffick...

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Detalles Bibliográficos
Autores principales:	Mercier, Aurélie, Clément, Romain, Harnois, Thomas, Bourmeyster, Nicolas, Faivre, Jean-François, Findlay, Ian, Chahine, Mohamed, Bois, Patrick, Chatelier, Aurélien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486797/ https://www.ncbi.nlm.nih.gov/pubmed/23133651 http://dx.doi.org/10.1371/journal.pone.0048690

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