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A Peptide Binding to the β-Site of APP Improves Spatial Memory and Attenuates Aβ Burden in Alzheimer’s Disease Transgenic Mice

Amyloid precursor protein cleaving enzyme 1 (BACE1), an aspartyl protease, initiates processing of the amyloid precursor protein (APP) into β-amyloid (Aβ); the peptide likely contributes to development of Alzheimer’s disease (AD). BACE1 is an attractive therapeutic target for AD treatment, but it ex...

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Detalles Bibliográficos
Autores principales:	Yang, Shi-gao, Wang, Shao-wei, Zhao, Min, Zhang, Ran, Zhou, Wei-wei, Li, Ya-nan, Su, Ya-jing, Zhang, He, Yu, Xiao-lin, Liu, Rui-tian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486805/ https://www.ncbi.nlm.nih.gov/pubmed/23133641 http://dx.doi.org/10.1371/journal.pone.0048540

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