A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis

Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous for the mutation die early during embryonic de...

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Detalles Bibliográficos
Autores principales: Bagley, Bruce N., Keane, Thomas M., Maklakova, Vilena I., Marshall, Jonathon G., Lester, Rachael A., Cancel, Michelle M., Paulsen, Alex R., Bendzick, Laura E., Been, Raha A., Kogan, Scott C., Cormier, Robert T., Kendziorski, Christina, Adams, David J., Collier, Lara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486839/
https://www.ncbi.nlm.nih.gov/pubmed/23133403
http://dx.doi.org/10.1371/journal.pgen.1003034

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