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Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (−/−) Mice and Effects on Mammalian GABA(A) Channel Activity

The anthelmintics ivermectin (IVM) and moxidectin (MOX) display differences in toxicity in several host species. Entrance into the brain is restricted by the P-glycoprotein (P-gp) efflux transporter, while toxicity is mediated through the brain GABA(A) receptors. This study compared the toxicity of...

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Detalles Bibliográficos
Autores principales:	Ménez, Cécile, Sutra, Jean-François, Prichard, Roger, Lespine, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486876/ https://www.ncbi.nlm.nih.gov/pubmed/23133688 http://dx.doi.org/10.1371/journal.pntd.0001883

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