Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is a key antigen that elicits protective immunity against the meningococcus and recruits the host complement regula...

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Detalles Bibliográficos
Autores principales: Johnson, Steven, Tan, Lionel, van der Veen, Stijn, Caesar, Joseph, Goicoechea De Jorge, Elena, Harding, Rachel J., Bai, Xilian, Exley, Rachel M., Ward, Philip N., Ruivo, Nicola, Trivedi, Kaushali, Cumber, Elspeth, Jones, Rhian, Newham, Luke, Staunton, David, Ufret-Vincenty, Rafael, Borrow, Ray, Pickering, Matthew C., Lea, Susan M., Tang, Christoph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486911/
https://www.ncbi.nlm.nih.gov/pubmed/23133374
http://dx.doi.org/10.1371/journal.ppat.1002981

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