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Differences in airway inflammation according to atopic status in patients with chronic rhinitis

BACKGROUND: Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease." OBJECTIVE: This study was conducted to evaluate differences between the different forms of chronic rhiniti...

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Autores principales: Kwon, Jae-Woo, Kim, Tae-Wan, Kim, Kyung-Mook, Jung, Jae-Woo, Cho, Sang-Heon, Min, Kyung-Up, Kim, You-Young, Park, Heung-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486969/
https://www.ncbi.nlm.nih.gov/pubmed/23130330
http://dx.doi.org/10.5415/apallergy.2012.2.4.248
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author Kwon, Jae-Woo
Kim, Tae-Wan
Kim, Kyung-Mook
Jung, Jae-Woo
Cho, Sang-Heon
Min, Kyung-Up
Kim, You-Young
Park, Heung-Woo
author_facet Kwon, Jae-Woo
Kim, Tae-Wan
Kim, Kyung-Mook
Jung, Jae-Woo
Cho, Sang-Heon
Min, Kyung-Up
Kim, You-Young
Park, Heung-Woo
author_sort Kwon, Jae-Woo
collection PubMed
description BACKGROUND: Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease." OBJECTIVE: This study was conducted to evaluate differences between the different forms of chronic rhinitis in terms of lower airway inflammation. METHODS: Patients that attended the allergy clinic and presented with moderate/severe persistent rhinitis symptoms for more than 1 year were enrolled. The patients with chronic rhinitis were classified into two groups (house dust mites [HDM]-sensitive allergic rhinitis [AR] or non-allergic rhinitis [NAR]) according to the presence of atopy, and additionally according to nasal polyposis and airway hyperresponsiveness, respectively. Medical records were reviewed and the mRNA expression levels of IL-5, IFN-γ, TGF-β1, IL-17A, and IL-25 were evaluated in induced sputum samples in each group. RESULTS: Induced sputum samples of 53 patients were evaluated. Patients with NAR were significantly older than patients with HDM-sensitive AR (p < 0.05). Nasal polyposis was more prevalent in NAR patients than in HDM-sensitive AR patients (10.2% vs. 62.5%, p < 0.001). The expression levels of IL-17A mRNA were higher in NAR patients, regardless of the presence of airway hyperresponsiveness (p = 0.005). CONCLUSION: These results suggest that patients with different forms of chronic rhinitis could have different inflammatory environments in their lower airway and NAR patients might have bronchial inflammation related to the elevated levels of IL-17A compared to HDM-sensitive AR patients.
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spelling pubmed-34869692012-11-05 Differences in airway inflammation according to atopic status in patients with chronic rhinitis Kwon, Jae-Woo Kim, Tae-Wan Kim, Kyung-Mook Jung, Jae-Woo Cho, Sang-Heon Min, Kyung-Up Kim, You-Young Park, Heung-Woo Asia Pac Allergy Original Article BACKGROUND: Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease." OBJECTIVE: This study was conducted to evaluate differences between the different forms of chronic rhinitis in terms of lower airway inflammation. METHODS: Patients that attended the allergy clinic and presented with moderate/severe persistent rhinitis symptoms for more than 1 year were enrolled. The patients with chronic rhinitis were classified into two groups (house dust mites [HDM]-sensitive allergic rhinitis [AR] or non-allergic rhinitis [NAR]) according to the presence of atopy, and additionally according to nasal polyposis and airway hyperresponsiveness, respectively. Medical records were reviewed and the mRNA expression levels of IL-5, IFN-γ, TGF-β1, IL-17A, and IL-25 were evaluated in induced sputum samples in each group. RESULTS: Induced sputum samples of 53 patients were evaluated. Patients with NAR were significantly older than patients with HDM-sensitive AR (p < 0.05). Nasal polyposis was more prevalent in NAR patients than in HDM-sensitive AR patients (10.2% vs. 62.5%, p < 0.001). The expression levels of IL-17A mRNA were higher in NAR patients, regardless of the presence of airway hyperresponsiveness (p = 0.005). CONCLUSION: These results suggest that patients with different forms of chronic rhinitis could have different inflammatory environments in their lower airway and NAR patients might have bronchial inflammation related to the elevated levels of IL-17A compared to HDM-sensitive AR patients. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2012-10 2012-10-31 /pmc/articles/PMC3486969/ /pubmed/23130330 http://dx.doi.org/10.5415/apallergy.2012.2.4.248 Text en Copyright © 2012. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kwon, Jae-Woo
Kim, Tae-Wan
Kim, Kyung-Mook
Jung, Jae-Woo
Cho, Sang-Heon
Min, Kyung-Up
Kim, You-Young
Park, Heung-Woo
Differences in airway inflammation according to atopic status in patients with chronic rhinitis
title Differences in airway inflammation according to atopic status in patients with chronic rhinitis
title_full Differences in airway inflammation according to atopic status in patients with chronic rhinitis
title_fullStr Differences in airway inflammation according to atopic status in patients with chronic rhinitis
title_full_unstemmed Differences in airway inflammation according to atopic status in patients with chronic rhinitis
title_short Differences in airway inflammation according to atopic status in patients with chronic rhinitis
title_sort differences in airway inflammation according to atopic status in patients with chronic rhinitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486969/
https://www.ncbi.nlm.nih.gov/pubmed/23130330
http://dx.doi.org/10.5415/apallergy.2012.2.4.248
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