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Differences in airway inflammation according to atopic status in patients with chronic rhinitis
BACKGROUND: Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease." OBJECTIVE: This study was conducted to evaluate differences between the different forms of chronic rhiniti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486969/ https://www.ncbi.nlm.nih.gov/pubmed/23130330 http://dx.doi.org/10.5415/apallergy.2012.2.4.248 |
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author | Kwon, Jae-Woo Kim, Tae-Wan Kim, Kyung-Mook Jung, Jae-Woo Cho, Sang-Heon Min, Kyung-Up Kim, You-Young Park, Heung-Woo |
author_facet | Kwon, Jae-Woo Kim, Tae-Wan Kim, Kyung-Mook Jung, Jae-Woo Cho, Sang-Heon Min, Kyung-Up Kim, You-Young Park, Heung-Woo |
author_sort | Kwon, Jae-Woo |
collection | PubMed |
description | BACKGROUND: Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease." OBJECTIVE: This study was conducted to evaluate differences between the different forms of chronic rhinitis in terms of lower airway inflammation. METHODS: Patients that attended the allergy clinic and presented with moderate/severe persistent rhinitis symptoms for more than 1 year were enrolled. The patients with chronic rhinitis were classified into two groups (house dust mites [HDM]-sensitive allergic rhinitis [AR] or non-allergic rhinitis [NAR]) according to the presence of atopy, and additionally according to nasal polyposis and airway hyperresponsiveness, respectively. Medical records were reviewed and the mRNA expression levels of IL-5, IFN-γ, TGF-β1, IL-17A, and IL-25 were evaluated in induced sputum samples in each group. RESULTS: Induced sputum samples of 53 patients were evaluated. Patients with NAR were significantly older than patients with HDM-sensitive AR (p < 0.05). Nasal polyposis was more prevalent in NAR patients than in HDM-sensitive AR patients (10.2% vs. 62.5%, p < 0.001). The expression levels of IL-17A mRNA were higher in NAR patients, regardless of the presence of airway hyperresponsiveness (p = 0.005). CONCLUSION: These results suggest that patients with different forms of chronic rhinitis could have different inflammatory environments in their lower airway and NAR patients might have bronchial inflammation related to the elevated levels of IL-17A compared to HDM-sensitive AR patients. |
format | Online Article Text |
id | pubmed-3486969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-34869692012-11-05 Differences in airway inflammation according to atopic status in patients with chronic rhinitis Kwon, Jae-Woo Kim, Tae-Wan Kim, Kyung-Mook Jung, Jae-Woo Cho, Sang-Heon Min, Kyung-Up Kim, You-Young Park, Heung-Woo Asia Pac Allergy Original Article BACKGROUND: Chronic rhinitis is a heterogeneous group of diseases that cause nasal inflammation. And the nose may be a window into the lung in the concept of "one airway one disease." OBJECTIVE: This study was conducted to evaluate differences between the different forms of chronic rhinitis in terms of lower airway inflammation. METHODS: Patients that attended the allergy clinic and presented with moderate/severe persistent rhinitis symptoms for more than 1 year were enrolled. The patients with chronic rhinitis were classified into two groups (house dust mites [HDM]-sensitive allergic rhinitis [AR] or non-allergic rhinitis [NAR]) according to the presence of atopy, and additionally according to nasal polyposis and airway hyperresponsiveness, respectively. Medical records were reviewed and the mRNA expression levels of IL-5, IFN-γ, TGF-β1, IL-17A, and IL-25 were evaluated in induced sputum samples in each group. RESULTS: Induced sputum samples of 53 patients were evaluated. Patients with NAR were significantly older than patients with HDM-sensitive AR (p < 0.05). Nasal polyposis was more prevalent in NAR patients than in HDM-sensitive AR patients (10.2% vs. 62.5%, p < 0.001). The expression levels of IL-17A mRNA were higher in NAR patients, regardless of the presence of airway hyperresponsiveness (p = 0.005). CONCLUSION: These results suggest that patients with different forms of chronic rhinitis could have different inflammatory environments in their lower airway and NAR patients might have bronchial inflammation related to the elevated levels of IL-17A compared to HDM-sensitive AR patients. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2012-10 2012-10-31 /pmc/articles/PMC3486969/ /pubmed/23130330 http://dx.doi.org/10.5415/apallergy.2012.2.4.248 Text en Copyright © 2012. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kwon, Jae-Woo Kim, Tae-Wan Kim, Kyung-Mook Jung, Jae-Woo Cho, Sang-Heon Min, Kyung-Up Kim, You-Young Park, Heung-Woo Differences in airway inflammation according to atopic status in patients with chronic rhinitis |
title | Differences in airway inflammation according to atopic status in patients with chronic rhinitis |
title_full | Differences in airway inflammation according to atopic status in patients with chronic rhinitis |
title_fullStr | Differences in airway inflammation according to atopic status in patients with chronic rhinitis |
title_full_unstemmed | Differences in airway inflammation according to atopic status in patients with chronic rhinitis |
title_short | Differences in airway inflammation according to atopic status in patients with chronic rhinitis |
title_sort | differences in airway inflammation according to atopic status in patients with chronic rhinitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486969/ https://www.ncbi.nlm.nih.gov/pubmed/23130330 http://dx.doi.org/10.5415/apallergy.2012.2.4.248 |
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