Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

BACKGROUND: Macrophage‐mediated chronic inflammation is mechanistically linked to insulin resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role of arginase II (Arg‐II) in macrophage function remains elusive. This study characterizes the role of Arg‐II in macrop...

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Detalles Bibliográficos
Autores principales: Ming, Xiu‐Fen, Rajapakse, Angana G., Yepuri, Gautham, Xiong, Yuyan, Carvas, João M., Ruffieux, Jean, Scerri, Isabelle, Wu, Zongsong, Popp, Katja, Li, Jianhui, Sartori, Claudio, Scherrer, Urs, Kwak, Brenda R., Montani, Jean‐Pierre, Yang, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487353/
https://www.ncbi.nlm.nih.gov/pubmed/23130157
http://dx.doi.org/10.1161/JAHA.112.000992

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