Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003–2008

Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii –A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains fro...

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Detalles Bibliográficos
Autores principales: HUANG, X.-Z., CHAHINE, M. A., FRYE, J. G., CASH, D. M., LESHO, E. P., CRAFT, D. W., LINDLER, L. E., NIKOLICH, M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487480/
https://www.ncbi.nlm.nih.gov/pubmed/22273504
http://dx.doi.org/10.1017/S0950268811002871
Descripción
Sumario:Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii –A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003–2008. All IR strains carried the bla(OXA-51) gene and 40 also carried bla(OXA-23) on plasmids and/or chromosome; one carried bla(OXA-58) and four contained ISAbal located upstream of bla(OXA-51). Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.

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