Cargando…
Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocu...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487483/ https://www.ncbi.nlm.nih.gov/pubmed/22370165 http://dx.doi.org/10.1017/S0950268812000192 |
_version_ | 1782248484885233664 |
---|---|
author | McCARTHY, N. D. GILLESPIE, I. A. LAWSON, A. J. RICHARDSON, J. NEAL, K. R. HAWTIN, P. R. MAIDEN, M. C. J. O'BRIEN, S. J. |
author_facet | McCARTHY, N. D. GILLESPIE, I. A. LAWSON, A. J. RICHARDSON, J. NEAL, K. R. HAWTIN, P. R. MAIDEN, M. C. J. O'BRIEN, S. J. |
author_sort | McCARTHY, N. D. |
collection | PubMed |
description | We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocus sequence-typed. Analyses compared pathogen population structure between areas, over time, and between clinical presentations. Pooled analysis was performed with published international datasets. Subtype association with virulence was not observed. UK sites had nearly identical C. jejuni populations. A clade formed by ST45 and ST283 clonal complexes showed a summer peak. This clade was common in a Finnish dataset but not in New Zealand and Australian collections, countries with less marked seasonality. The UK, New Zealand and Australian collections were otherwise similar. These findings map to known in-vitro differences of this clade. This identifies a target for studies to elucidate the drivers of the summer peak in human C. jejuni infection. |
format | Online Article Text |
id | pubmed-3487483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34874832012-12-01 Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease McCARTHY, N. D. GILLESPIE, I. A. LAWSON, A. J. RICHARDSON, J. NEAL, K. R. HAWTIN, P. R. MAIDEN, M. C. J. O'BRIEN, S. J. Epidemiol Infect Original Papers We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocus sequence-typed. Analyses compared pathogen population structure between areas, over time, and between clinical presentations. Pooled analysis was performed with published international datasets. Subtype association with virulence was not observed. UK sites had nearly identical C. jejuni populations. A clade formed by ST45 and ST283 clonal complexes showed a summer peak. This clade was common in a Finnish dataset but not in New Zealand and Australian collections, countries with less marked seasonality. The UK, New Zealand and Australian collections were otherwise similar. These findings map to known in-vitro differences of this clade. This identifies a target for studies to elucidate the drivers of the summer peak in human C. jejuni infection. Cambridge University Press 2012-12 2012-02-28 /pmc/articles/PMC3487483/ /pubmed/22370165 http://dx.doi.org/10.1017/S0950268812000192 Text en © Cambridge University Press 2012 https://creativecommons.org/licenses/by-nc-sa/2.5/The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/ (https://creativecommons.org/licenses/by-nc-sa/2.5/) >. The written permission of Cambridge University Press must be obtained for commercial re-use. |
spellingShingle | Original Papers McCARTHY, N. D. GILLESPIE, I. A. LAWSON, A. J. RICHARDSON, J. NEAL, K. R. HAWTIN, P. R. MAIDEN, M. C. J. O'BRIEN, S. J. Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease |
title | Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease |
title_full | Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease |
title_fullStr | Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease |
title_full_unstemmed | Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease |
title_short | Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease |
title_sort | molecular epidemiology of human campylobacter jejuni shows association between seasonal and international patterns of disease |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487483/ https://www.ncbi.nlm.nih.gov/pubmed/22370165 http://dx.doi.org/10.1017/S0950268812000192 |
work_keys_str_mv | AT mccarthynd molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT gillespieia molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT lawsonaj molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT richardsonj molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT nealkr molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT hawtinpr molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT maidenmcj molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease AT obriensj molecularepidemiologyofhumancampylobacterjejunishowsassociationbetweenseasonalandinternationalpatternsofdisease |