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Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease

We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocu...

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Autores principales: McCARTHY, N. D., GILLESPIE, I. A., LAWSON, A. J., RICHARDSON, J., NEAL, K. R., HAWTIN, P. R., MAIDEN, M. C. J., O'BRIEN, S. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487483/
https://www.ncbi.nlm.nih.gov/pubmed/22370165
http://dx.doi.org/10.1017/S0950268812000192
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author McCARTHY, N. D.
GILLESPIE, I. A.
LAWSON, A. J.
RICHARDSON, J.
NEAL, K. R.
HAWTIN, P. R.
MAIDEN, M. C. J.
O'BRIEN, S. J.
author_facet McCARTHY, N. D.
GILLESPIE, I. A.
LAWSON, A. J.
RICHARDSON, J.
NEAL, K. R.
HAWTIN, P. R.
MAIDEN, M. C. J.
O'BRIEN, S. J.
author_sort McCARTHY, N. D.
collection PubMed
description We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocus sequence-typed. Analyses compared pathogen population structure between areas, over time, and between clinical presentations. Pooled analysis was performed with published international datasets. Subtype association with virulence was not observed. UK sites had nearly identical C. jejuni populations. A clade formed by ST45 and ST283 clonal complexes showed a summer peak. This clade was common in a Finnish dataset but not in New Zealand and Australian collections, countries with less marked seasonality. The UK, New Zealand and Australian collections were otherwise similar. These findings map to known in-vitro differences of this clade. This identifies a target for studies to elucidate the drivers of the summer peak in human C. jejuni infection.
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spelling pubmed-34874832012-12-01 Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease McCARTHY, N. D. GILLESPIE, I. A. LAWSON, A. J. RICHARDSON, J. NEAL, K. R. HAWTIN, P. R. MAIDEN, M. C. J. O'BRIEN, S. J. Epidemiol Infect Original Papers We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocus sequence-typed. Analyses compared pathogen population structure between areas, over time, and between clinical presentations. Pooled analysis was performed with published international datasets. Subtype association with virulence was not observed. UK sites had nearly identical C. jejuni populations. A clade formed by ST45 and ST283 clonal complexes showed a summer peak. This clade was common in a Finnish dataset but not in New Zealand and Australian collections, countries with less marked seasonality. The UK, New Zealand and Australian collections were otherwise similar. These findings map to known in-vitro differences of this clade. This identifies a target for studies to elucidate the drivers of the summer peak in human C. jejuni infection. Cambridge University Press 2012-12 2012-02-28 /pmc/articles/PMC3487483/ /pubmed/22370165 http://dx.doi.org/10.1017/S0950268812000192 Text en © Cambridge University Press 2012 https://creativecommons.org/licenses/by-nc-sa/2.5/The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/ (https://creativecommons.org/licenses/by-nc-sa/2.5/) >. The written permission of Cambridge University Press must be obtained for commercial re-use.
spellingShingle Original Papers
McCARTHY, N. D.
GILLESPIE, I. A.
LAWSON, A. J.
RICHARDSON, J.
NEAL, K. R.
HAWTIN, P. R.
MAIDEN, M. C. J.
O'BRIEN, S. J.
Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
title Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
title_full Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
title_fullStr Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
title_full_unstemmed Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
title_short Molecular epidemiology of human Campylobacter jejuni shows association between seasonal and international patterns of disease
title_sort molecular epidemiology of human campylobacter jejuni shows association between seasonal and international patterns of disease
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487483/
https://www.ncbi.nlm.nih.gov/pubmed/22370165
http://dx.doi.org/10.1017/S0950268812000192
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