Conformations of Islet Amyloid Polypeptide Monomers in a Membrane Environment: Implications for Fibril Formation

The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II diabetes. One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane damage. The fatal mutation of S20G human IAPP was reported to lead to early onset of type II diabetes and high tenden...

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Detalles Bibliográficos
Autores principales: Duan, Mojie, Fan, Jue, Huo, Shuanghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487734/
https://www.ncbi.nlm.nih.gov/pubmed/23133593
http://dx.doi.org/10.1371/journal.pone.0047150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487734/
https://www.ncbi.nlm.nih.gov/pubmed/23133593
http://dx.doi.org/10.1371/journal.pone.0047150

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