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Conformations of Islet Amyloid Polypeptide Monomers in a Membrane Environment: Implications for Fibril Formation
The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II diabetes. One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane damage. The fatal mutation of S20G human IAPP was reported to lead to early onset of type II diabetes and high tenden...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487734/ https://www.ncbi.nlm.nih.gov/pubmed/23133593 http://dx.doi.org/10.1371/journal.pone.0047150 |