Dasatinib Inhibits CXCR4 Signaling in Chronic Lymphocytic Leukaemia Cells and Impairs Migration Towards CXCL12

Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling pathways has become a novel therapeutic approach i...

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Detalles Bibliográficos
Autores principales: McCaig, Alison M., Cosimo, Emilio, Leach, Michael T., Michie, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487834/
https://www.ncbi.nlm.nih.gov/pubmed/23133664
http://dx.doi.org/10.1371/journal.pone.0048929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487834/
https://www.ncbi.nlm.nih.gov/pubmed/23133664
http://dx.doi.org/10.1371/journal.pone.0048929

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