NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax

Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsukahara, Tomohide, Takasawa, Akira, Murata, Masaki, Okumura, Kazuyoshi, Nakayama, Masato, Sato, Noriyuki, Hasegawa, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487841/
https://www.ncbi.nlm.nih.gov/pubmed/22931631
http://dx.doi.org/10.1186/1746-1596-7-114
_version_ 1782248527775137792
author Tsukahara, Tomohide
Takasawa, Akira
Murata, Masaki
Okumura, Kazuyoshi
Nakayama, Masato
Sato, Noriyuki
Hasegawa, Tadashi
author_facet Tsukahara, Tomohide
Takasawa, Akira
Murata, Masaki
Okumura, Kazuyoshi
Nakayama, Masato
Sato, Noriyuki
Hasegawa, Tadashi
author_sort Tsukahara, Tomohide
collection PubMed
description Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-, CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854.
format Online
Article
Text
id pubmed-3487841
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34878412012-11-03 NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax Tsukahara, Tomohide Takasawa, Akira Murata, Masaki Okumura, Kazuyoshi Nakayama, Masato Sato, Noriyuki Hasegawa, Tadashi Diagn Pathol Case Report Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-, CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854. BioMed Central 2012-08-29 /pmc/articles/PMC3487841/ /pubmed/22931631 http://dx.doi.org/10.1186/1746-1596-7-114 Text en Copyright ©2012 Tsukahara et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tsukahara, Tomohide
Takasawa, Akira
Murata, Masaki
Okumura, Kazuyoshi
Nakayama, Masato
Sato, Noriyuki
Hasegawa, Tadashi
NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
title NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
title_full NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
title_fullStr NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
title_full_unstemmed NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
title_short NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
title_sort nk/t-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487841/
https://www.ncbi.nlm.nih.gov/pubmed/22931631
http://dx.doi.org/10.1186/1746-1596-7-114
work_keys_str_mv AT tsukaharatomohide nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax
AT takasawaakira nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax
AT muratamasaki nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax
AT okumurakazuyoshi nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax
AT nakayamamasato nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax
AT satonoriyuki nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax
AT hasegawatadashi nktcelllymphomaofbilateraladrenalglandsinapatientwithpyothorax

Ejemplares similares