Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

BACKGROUND: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore are expected to revert quickly. Compensatory mutations, often al...

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Detalles Bibliográficos
Autores principales: Theys, Kristof, Deforche, Koen, Vercauteren, Jurgen, Libin, Pieter, van de Vijver, David AMC, Albert, Jan, Åsjö, Birgitta, Balotta, Claudia, Bruckova, Marie, Camacho, Ricardo J, Clotet, Bonaventura, Coughlan, Suzie, Grossman, Zehava, Hamouda, Osamah, Horban, Andrzei, Korn, Klaus, Kostrikis, Leondios G, Kücherer, Claudia, Nielsen, Claus, Paraskevis, Dimitrios, Poljak, Mario, Puchhammer-Stockl, Elisabeth, Riva, Chiara, Ruiz, Lidia, Liitsola, Kirsi, Schmit, Jean-Claude, Schuurman, Rob, Sönnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Struck, Daniel, Van Laethem, Kristel, Wensing, Annemarie MJ, Boucher, Charles AB, Vandamme, Anne-Mieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487874/
https://www.ncbi.nlm.nih.gov/pubmed/23031662
http://dx.doi.org/10.1186/1742-4690-9-81

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