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Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study

AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). METHODS: Twenty-s...

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Autores principales: Liu, Chun-Hong, Ma, Xin, Li, Feng, Wang, Yong-Jun, Tie, Chang-Le, Li, Su-Fang, Chen, Tao-Lin, Fan, Ting-ting, Zhang, Yu, Dong, Jie, Yao, Li, Wu, Xia, Wang, Chuan-Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487908/
https://www.ncbi.nlm.nih.gov/pubmed/23133615
http://dx.doi.org/10.1371/journal.pone.0048181
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author Liu, Chun-Hong
Ma, Xin
Li, Feng
Wang, Yong-Jun
Tie, Chang-Le
Li, Su-Fang
Chen, Tao-Lin
Fan, Ting-ting
Zhang, Yu
Dong, Jie
Yao, Li
Wu, Xia
Wang, Chuan-Yue
author_facet Liu, Chun-Hong
Ma, Xin
Li, Feng
Wang, Yong-Jun
Tie, Chang-Le
Li, Su-Fang
Chen, Tao-Lin
Fan, Ting-ting
Zhang, Yu
Dong, Jie
Yao, Li
Wu, Xia
Wang, Chuan-Yue
author_sort Liu, Chun-Hong
collection PubMed
description AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). METHODS: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. RESULTS: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. CONCLUSIONS: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.
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spelling pubmed-34879082012-11-06 Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study Liu, Chun-Hong Ma, Xin Li, Feng Wang, Yong-Jun Tie, Chang-Le Li, Su-Fang Chen, Tao-Lin Fan, Ting-ting Zhang, Yu Dong, Jie Yao, Li Wu, Xia Wang, Chuan-Yue PLoS One Research Article AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). METHODS: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. RESULTS: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. CONCLUSIONS: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression. Public Library of Science 2012-11-02 /pmc/articles/PMC3487908/ /pubmed/23133615 http://dx.doi.org/10.1371/journal.pone.0048181 Text en © 2012 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Chun-Hong
Ma, Xin
Li, Feng
Wang, Yong-Jun
Tie, Chang-Le
Li, Su-Fang
Chen, Tao-Lin
Fan, Ting-ting
Zhang, Yu
Dong, Jie
Yao, Li
Wu, Xia
Wang, Chuan-Yue
Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
title Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
title_full Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
title_fullStr Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
title_full_unstemmed Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
title_short Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
title_sort regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487908/
https://www.ncbi.nlm.nih.gov/pubmed/23133615
http://dx.doi.org/10.1371/journal.pone.0048181
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