Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males

BACKGROUND: SPAG16 is a critical structural component of motile cilia and flagella. In the eukaryotic unicellular algae Chlamydomonas, loss of gene function causes flagellar paralysis and prevents assembly of the “9 + 2” axoneme central pair. In mice, we have previously shown that loss of Spag16 gen...

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Detalles Bibliográficos
Autores principales: Nagarkatti-Gude, David R, Collodel, Giulia, Hill, Lori D, Moretti, Elena, Geminiani, Michela, Zhang, Zhibing, Strauss, Jerome F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487941/
https://www.ncbi.nlm.nih.gov/pubmed/22963137
http://dx.doi.org/10.1186/1471-2490-12-27

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