Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte

The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). The PV and host cell membranes eventually rupture, releasing merozoites in a process called egress. Certain inhibitors of serine and cysteine proteases block egress, indicating a crucial role for proteases. The...

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Detalles Bibliográficos
Autores principales: Ruecker, Andrea, Shea, Michael, Hackett, Fiona, Suarez, Catherine, Hirst, Elizabeth M. A., Milutinovic, Katarina, Withers-Martinez, Chrislaine, Blackman, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488066/
https://www.ncbi.nlm.nih.gov/pubmed/22984267
http://dx.doi.org/10.1074/jbc.M112.400820

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