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Elevated plasma levels of TIMP-1 in patients with rotator cuff tear

BACKGROUND AND PURPOSE: Extracellular matrix remodeling is altered in rotator cuff tears, partly due to altered expression of matrix metalloproteinases (MMPs) and their inhibitors. It is unclear whether this altered expression can be traced as changes in plasma protein levels. We measured the plasma...

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Autores principales: Hallgren, Hanna C Björnsson, Eliasson, Pernilla, Aspenberg, Per, Adolfsson, Lars E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488181/
https://www.ncbi.nlm.nih.gov/pubmed/23043271
http://dx.doi.org/10.3109/17453674.2012.736174
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author Hallgren, Hanna C Björnsson
Eliasson, Pernilla
Aspenberg, Per
Adolfsson, Lars E
author_facet Hallgren, Hanna C Björnsson
Eliasson, Pernilla
Aspenberg, Per
Adolfsson, Lars E
author_sort Hallgren, Hanna C Björnsson
collection PubMed
description BACKGROUND AND PURPOSE: Extracellular matrix remodeling is altered in rotator cuff tears, partly due to altered expression of matrix metalloproteinases (MMPs) and their inhibitors. It is unclear whether this altered expression can be traced as changes in plasma protein levels. We measured the plasma levels of MMPs and their tissue inhibitors (TIMPs) in patients with rotator cuff tears and related changes in the pattern of MMP and TIMP levels to the extent of the rotator cuff tear. METHODS: Blood samples were collected from 17 patients, median age 61 (39–77) years, with sonographically verified rotator cuff tears (partial- or full-thickness). These were compared with 16 age- and sex-matched control individuals with sonographically intact rotator cuffs. Plasma levels of MMPs and TIMPs were measured simultaneously using Luminex technology and ELISA. RESULTS: The plasma levels of TIMP-1 were elevated in patients with rotator cuff tears, especially in those with full-thickness tears. The levels of TIMP-1, TIMP-3, and MMP-9 were higher in patients with full-thickness tears than in those with partial-thickness tears, but only the TIMP-1 levels were significantly different from those in the controls. INTERPRETATION: The observed elevation of TIMP-1 in plasma might reflect local pathological processes in or around the rotator cuff, or a genetic predisposition in these patients. That the levels of TIMP-1 and of certain MMPs were found to differ significantly between partial and full-thickness tears may reflect the extent of the lesion or different etiology and pathomechanisms.
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spelling pubmed-34881812012-11-05 Elevated plasma levels of TIMP-1 in patients with rotator cuff tear Hallgren, Hanna C Björnsson Eliasson, Pernilla Aspenberg, Per Adolfsson, Lars E Acta Orthop Shoulder BACKGROUND AND PURPOSE: Extracellular matrix remodeling is altered in rotator cuff tears, partly due to altered expression of matrix metalloproteinases (MMPs) and their inhibitors. It is unclear whether this altered expression can be traced as changes in plasma protein levels. We measured the plasma levels of MMPs and their tissue inhibitors (TIMPs) in patients with rotator cuff tears and related changes in the pattern of MMP and TIMP levels to the extent of the rotator cuff tear. METHODS: Blood samples were collected from 17 patients, median age 61 (39–77) years, with sonographically verified rotator cuff tears (partial- or full-thickness). These were compared with 16 age- and sex-matched control individuals with sonographically intact rotator cuffs. Plasma levels of MMPs and TIMPs were measured simultaneously using Luminex technology and ELISA. RESULTS: The plasma levels of TIMP-1 were elevated in patients with rotator cuff tears, especially in those with full-thickness tears. The levels of TIMP-1, TIMP-3, and MMP-9 were higher in patients with full-thickness tears than in those with partial-thickness tears, but only the TIMP-1 levels were significantly different from those in the controls. INTERPRETATION: The observed elevation of TIMP-1 in plasma might reflect local pathological processes in or around the rotator cuff, or a genetic predisposition in these patients. That the levels of TIMP-1 and of certain MMPs were found to differ significantly between partial and full-thickness tears may reflect the extent of the lesion or different etiology and pathomechanisms. Informa Healthcare 2012-10 2012-10-22 /pmc/articles/PMC3488181/ /pubmed/23043271 http://dx.doi.org/10.3109/17453674.2012.736174 Text en Copyright: © Nordic Orthopaedic Federation http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Shoulder
Hallgren, Hanna C Björnsson
Eliasson, Pernilla
Aspenberg, Per
Adolfsson, Lars E
Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
title Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
title_full Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
title_fullStr Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
title_full_unstemmed Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
title_short Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
title_sort elevated plasma levels of timp-1 in patients with rotator cuff tear
topic Shoulder
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488181/
https://www.ncbi.nlm.nih.gov/pubmed/23043271
http://dx.doi.org/10.3109/17453674.2012.736174
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