Co-detection in the pathogenesis of severe hand-foot-mouth disease

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, nor...

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Detalles Bibliográficos
Autores principales: Liu, Li-Juan, Xu, Hong-Mei, Li, Xiu-Jun, Wang, Jun, Wang, Xian-Jun, Ding, Shu-Jun, Tang, Fang, Wang, Jing, Zhang, Ying-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488190/
https://www.ncbi.nlm.nih.gov/pubmed/22791110
http://dx.doi.org/10.1007/s00705-012-1396-6
Descripción
Sumario:It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.

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