Co-detection in the pathogenesis of severe hand-foot-mouth disease

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, nor...

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Autores principales: Liu, Li-Juan, Xu, Hong-Mei, Li, Xiu-Jun, Wang, Jun, Wang, Xian-Jun, Ding, Shu-Jun, Tang, Fang, Wang, Jing, Zhang, Ying-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488190/
https://www.ncbi.nlm.nih.gov/pubmed/22791110
http://dx.doi.org/10.1007/s00705-012-1396-6
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author Liu, Li-Juan
Xu, Hong-Mei
Li, Xiu-Jun
Wang, Jun
Wang, Xian-Jun
Ding, Shu-Jun
Tang, Fang
Wang, Jing
Zhang, Ying-Jie
author_facet Liu, Li-Juan
Xu, Hong-Mei
Li, Xiu-Jun
Wang, Jun
Wang, Xian-Jun
Ding, Shu-Jun
Tang, Fang
Wang, Jing
Zhang, Ying-Jie
author_sort Liu, Li-Juan
collection PubMed
description It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.
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spelling pubmed-34881902012-11-05 Co-detection in the pathogenesis of severe hand-foot-mouth disease Liu, Li-Juan Xu, Hong-Mei Li, Xiu-Jun Wang, Jun Wang, Xian-Jun Ding, Shu-Jun Tang, Fang Wang, Jing Zhang, Ying-Jie Arch Virol Brief Report It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD. Springer Vienna 2012-07-13 2012 /pmc/articles/PMC3488190/ /pubmed/22791110 http://dx.doi.org/10.1007/s00705-012-1396-6 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Brief Report
Liu, Li-Juan
Xu, Hong-Mei
Li, Xiu-Jun
Wang, Jun
Wang, Xian-Jun
Ding, Shu-Jun
Tang, Fang
Wang, Jing
Zhang, Ying-Jie
Co-detection in the pathogenesis of severe hand-foot-mouth disease
title Co-detection in the pathogenesis of severe hand-foot-mouth disease
title_full Co-detection in the pathogenesis of severe hand-foot-mouth disease
title_fullStr Co-detection in the pathogenesis of severe hand-foot-mouth disease
title_full_unstemmed Co-detection in the pathogenesis of severe hand-foot-mouth disease
title_short Co-detection in the pathogenesis of severe hand-foot-mouth disease
title_sort co-detection in the pathogenesis of severe hand-foot-mouth disease
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488190/
https://www.ncbi.nlm.nih.gov/pubmed/22791110
http://dx.doi.org/10.1007/s00705-012-1396-6
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