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Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update

Schizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in...

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Detalles Bibliográficos
Autores principales: Keilhoff, Gerburg, Fusar-Poli, Paolo, Becker, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488410/
https://www.ncbi.nlm.nih.gov/pubmed/23150836
http://dx.doi.org/10.1155/2012/832757
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author Keilhoff, Gerburg
Fusar-Poli, Paolo
Becker, Axel
author_facet Keilhoff, Gerburg
Fusar-Poli, Paolo
Becker, Axel
author_sort Keilhoff, Gerburg
collection PubMed
description Schizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in neurodevelopment might result in alterations of neuroanatomy and neurochemistry, leading to the typical symptoms observed in schizophrenia. The present paper will critically address the neurodevelopmental models underlying schizophrenia by discussing the effects of typical and atypical antipsychotics in animal models. We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset.
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spelling pubmed-34884102012-11-13 Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update Keilhoff, Gerburg Fusar-Poli, Paolo Becker, Axel Neural Plast Review Article Schizophrenia is a complex psychiatric disorder. Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it. There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role. Disturbances in neurodevelopment might result in alterations of neuroanatomy and neurochemistry, leading to the typical symptoms observed in schizophrenia. The present paper will critically address the neurodevelopmental models underlying schizophrenia by discussing the effects of typical and atypical antipsychotics in animal models. We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3488410/ /pubmed/23150836 http://dx.doi.org/10.1155/2012/832757 Text en Copyright © 2012 Gerburg Keilhoff et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Keilhoff, Gerburg
Fusar-Poli, Paolo
Becker, Axel
Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
title Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
title_full Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
title_fullStr Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
title_full_unstemmed Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
title_short Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
title_sort effects of antipsychotics on dentate gyrus stem cell proliferation and survival in animal models: a critical update
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488410/
https://www.ncbi.nlm.nih.gov/pubmed/23150836
http://dx.doi.org/10.1155/2012/832757
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