Cargando…
Challenges and Opportunities for Small Molecule Aptamer Development
Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488411/ https://www.ncbi.nlm.nih.gov/pubmed/23150810 http://dx.doi.org/10.1155/2012/748913 |
_version_ | 1782248613031706624 |
---|---|
author | McKeague, Maureen DeRosa, Maria C. |
author_facet | McKeague, Maureen DeRosa, Maria C. |
author_sort | McKeague, Maureen |
collection | PubMed |
description | Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology. |
format | Online Article Text |
id | pubmed-3488411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34884112012-11-13 Challenges and Opportunities for Small Molecule Aptamer Development McKeague, Maureen DeRosa, Maria C. J Nucleic Acids Review Article Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3488411/ /pubmed/23150810 http://dx.doi.org/10.1155/2012/748913 Text en Copyright © 2012 M. McKeague and M. C. DeRosa. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article McKeague, Maureen DeRosa, Maria C. Challenges and Opportunities for Small Molecule Aptamer Development |
title | Challenges and Opportunities for Small Molecule Aptamer Development |
title_full | Challenges and Opportunities for Small Molecule Aptamer Development |
title_fullStr | Challenges and Opportunities for Small Molecule Aptamer Development |
title_full_unstemmed | Challenges and Opportunities for Small Molecule Aptamer Development |
title_short | Challenges and Opportunities for Small Molecule Aptamer Development |
title_sort | challenges and opportunities for small molecule aptamer development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488411/ https://www.ncbi.nlm.nih.gov/pubmed/23150810 http://dx.doi.org/10.1155/2012/748913 |
work_keys_str_mv | AT mckeaguemaureen challengesandopportunitiesforsmallmoleculeaptamerdevelopment AT derosamariac challengesandopportunitiesforsmallmoleculeaptamerdevelopment |