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Challenges and Opportunities for Small Molecule Aptamer Development

Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small...

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Detalles Bibliográficos
Autores principales: McKeague, Maureen, DeRosa, Maria C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488411/
https://www.ncbi.nlm.nih.gov/pubmed/23150810
http://dx.doi.org/10.1155/2012/748913
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author McKeague, Maureen
DeRosa, Maria C.
author_facet McKeague, Maureen
DeRosa, Maria C.
author_sort McKeague, Maureen
collection PubMed
description Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.
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spelling pubmed-34884112012-11-13 Challenges and Opportunities for Small Molecule Aptamer Development McKeague, Maureen DeRosa, Maria C. J Nucleic Acids Review Article Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3488411/ /pubmed/23150810 http://dx.doi.org/10.1155/2012/748913 Text en Copyright © 2012 M. McKeague and M. C. DeRosa. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
McKeague, Maureen
DeRosa, Maria C.
Challenges and Opportunities for Small Molecule Aptamer Development
title Challenges and Opportunities for Small Molecule Aptamer Development
title_full Challenges and Opportunities for Small Molecule Aptamer Development
title_fullStr Challenges and Opportunities for Small Molecule Aptamer Development
title_full_unstemmed Challenges and Opportunities for Small Molecule Aptamer Development
title_short Challenges and Opportunities for Small Molecule Aptamer Development
title_sort challenges and opportunities for small molecule aptamer development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488411/
https://www.ncbi.nlm.nih.gov/pubmed/23150810
http://dx.doi.org/10.1155/2012/748913
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