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In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis

Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could signific...

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Autores principales: Ko, Chun-Hay, Siu, Wing-Sum, Wong, Hing-Lok, Gao, Si, Shum, Wai-Ting, Lau, Ching-Po, Cheng, Sau-Wan, Tam, Jacqueline Chor-Wing, Hung, Leung-Kim, Fung, Kwok-Pui, Lau, Clara Bik-San, Han, Quan-Bin, Leung, Ping-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488414/
https://www.ncbi.nlm.nih.gov/pubmed/23150739
http://dx.doi.org/10.1155/2012/203732
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author Ko, Chun-Hay
Siu, Wing-Sum
Wong, Hing-Lok
Gao, Si
Shum, Wai-Ting
Lau, Ching-Po
Cheng, Sau-Wan
Tam, Jacqueline Chor-Wing
Hung, Leung-Kim
Fung, Kwok-Pui
Lau, Clara Bik-San
Han, Quan-Bin
Leung, Ping-Chung
author_facet Ko, Chun-Hay
Siu, Wing-Sum
Wong, Hing-Lok
Gao, Si
Shum, Wai-Ting
Lau, Ching-Po
Cheng, Sau-Wan
Tam, Jacqueline Chor-Wing
Hung, Leung-Kim
Fung, Kwok-Pui
Lau, Clara Bik-San
Han, Quan-Bin
Leung, Ping-Chung
author_sort Ko, Chun-Hay
collection PubMed
description Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P = 0.014) and 5.94% (0.25 mg/kg/day of raloxifene; P = 0.026) when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P = 0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P = 0.02). However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced.
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spelling pubmed-34884142012-11-13 In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis Ko, Chun-Hay Siu, Wing-Sum Wong, Hing-Lok Gao, Si Shum, Wai-Ting Lau, Ching-Po Cheng, Sau-Wan Tam, Jacqueline Chor-Wing Hung, Leung-Kim Fung, Kwok-Pui Lau, Clara Bik-San Han, Quan-Bin Leung, Ping-Chung Evid Based Complement Alternat Med Research Article Antiresorptive drugs, alendronate and raloxifene, are effective in lowering bone mineral density (BMD) loss in postmenopausal women. However, long-term treatment may be associated with serious side effects. Our research group has recently discovered that a Chinese herbal formula, ELP, could significantly reduce BMD loss in animal and human studies. Therefore, the present study aimed to investigate the potential synergistic bone-protective effects of different herb-drug combinations using ovariectomized rats. To assess the efficacy of different combinations, the total BMD was monitored biweekly in the 8-week course of daily oral treatment. Bone microarchitecture, bone strength, and deoxypyridinoline level were also determined after 8 weeks. From our results, coadministration of ELP and raloxifene increased the total tibial BMD by 5.26% (2.5 mg/kg/day of raloxifene; P = 0.014) and 5.94% (0.25 mg/kg/day of raloxifene; P = 0.026) when compared with the respective dosage groups with raloxifene alone. Similar synergistic effects were also observed in BMD increase at distal femur (0.25 mg/kg/day; P = 0.001) and reduction in urinary deoxypyridinoline crosslink excretion (2.5 and 0.25 mg/kg/day; both P = 0.02). However, such interactions could not be observed in all alendronate-treated groups. Our data provide first evidence that ELP could synergistically enhance the therapeutic effects of raloxifene, so that the clinical dosage of raloxifene could be reduced. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3488414/ /pubmed/23150739 http://dx.doi.org/10.1155/2012/203732 Text en Copyright © 2012 Chun-Hay Ko et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ko, Chun-Hay
Siu, Wing-Sum
Wong, Hing-Lok
Gao, Si
Shum, Wai-Ting
Lau, Ching-Po
Cheng, Sau-Wan
Tam, Jacqueline Chor-Wing
Hung, Leung-Kim
Fung, Kwok-Pui
Lau, Clara Bik-San
Han, Quan-Bin
Leung, Ping-Chung
In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
title In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
title_full In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
title_fullStr In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
title_full_unstemmed In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
title_short In Vivo Study on the Pharmacological Interactions between a Chinese Herbal Formula ELP and Antiresorptive Drugs to Counteract Osteoporosis
title_sort in vivo study on the pharmacological interactions between a chinese herbal formula elp and antiresorptive drugs to counteract osteoporosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488414/
https://www.ncbi.nlm.nih.gov/pubmed/23150739
http://dx.doi.org/10.1155/2012/203732
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