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Vitreous Analysis in the Management of Uveitis

A correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefor...

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Autores principales: Damato, Erika M., Angi, Martina, Romano, Mario R., Semeraro, Francesco, Costagliola, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488417/
https://www.ncbi.nlm.nih.gov/pubmed/23150722
http://dx.doi.org/10.1155/2012/863418
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author Damato, Erika M.
Angi, Martina
Romano, Mario R.
Semeraro, Francesco
Costagliola, Ciro
author_facet Damato, Erika M.
Angi, Martina
Romano, Mario R.
Semeraro, Francesco
Costagliola, Ciro
author_sort Damato, Erika M.
collection PubMed
description A correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefore be used to provide the clinician with valuable information. In this paper, we describe the main clinical situations in which vitreous sampling is indicated and provide some guidance to clinicians for tailoring their requests. These situations include suspected intraocular infection and suspected intraocular malignancy. We describe the principal tests carried out on vitreous samples, including cultures, polymerase chain reaction-based testing, and cytokine analysis. Limitations of the tests used are likely to become less as more advanced testing methods are introduced. The importance of selecting the appropriate investigations to support a clinical suspicion is emphasised, as is the interpretation of test results within a clinical context.
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spelling pubmed-34884172012-11-13 Vitreous Analysis in the Management of Uveitis Damato, Erika M. Angi, Martina Romano, Mario R. Semeraro, Francesco Costagliola, Ciro Mediators Inflamm Review Article A correct diagnosis of uveitis is often challenging, given the wide range of possible underlying conditions and the lack of typical phenotypes. Management decisions may be difficult in view of the risk of visual loss with either inappropriate or delayed therapy. Analysis of the vitreous may therefore be used to provide the clinician with valuable information. In this paper, we describe the main clinical situations in which vitreous sampling is indicated and provide some guidance to clinicians for tailoring their requests. These situations include suspected intraocular infection and suspected intraocular malignancy. We describe the principal tests carried out on vitreous samples, including cultures, polymerase chain reaction-based testing, and cytokine analysis. Limitations of the tests used are likely to become less as more advanced testing methods are introduced. The importance of selecting the appropriate investigations to support a clinical suspicion is emphasised, as is the interpretation of test results within a clinical context. Hindawi Publishing Corporation 2012 2012-10-24 /pmc/articles/PMC3488417/ /pubmed/23150722 http://dx.doi.org/10.1155/2012/863418 Text en Copyright © 2012 Erika M. Damato et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Damato, Erika M.
Angi, Martina
Romano, Mario R.
Semeraro, Francesco
Costagliola, Ciro
Vitreous Analysis in the Management of Uveitis
title Vitreous Analysis in the Management of Uveitis
title_full Vitreous Analysis in the Management of Uveitis
title_fullStr Vitreous Analysis in the Management of Uveitis
title_full_unstemmed Vitreous Analysis in the Management of Uveitis
title_short Vitreous Analysis in the Management of Uveitis
title_sort vitreous analysis in the management of uveitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488417/
https://www.ncbi.nlm.nih.gov/pubmed/23150722
http://dx.doi.org/10.1155/2012/863418
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