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Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract

BACKGROUND: In patients with cancers of the pancreatic and biliary tract quality of life (QOL) improvement is the main treatment goal, since survival can be prolonged only marginally. Up to date, knowledge on QOL impairments throughout the entire treatment process, often including several chemothera...

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Autores principales: Zabernigg, August, Giesinger, Johannes M, Pall, Georg, Gamper, Eva-Maria, Gattringer, Klaus, Wintner, Lisa M, Sztankay, Monika J, Holzner, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488526/
https://www.ncbi.nlm.nih.gov/pubmed/22950826
http://dx.doi.org/10.1186/1471-2407-12-390
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author Zabernigg, August
Giesinger, Johannes M
Pall, Georg
Gamper, Eva-Maria
Gattringer, Klaus
Wintner, Lisa M
Sztankay, Monika J
Holzner, Bernhard
author_facet Zabernigg, August
Giesinger, Johannes M
Pall, Georg
Gamper, Eva-Maria
Gattringer, Klaus
Wintner, Lisa M
Sztankay, Monika J
Holzner, Bernhard
author_sort Zabernigg, August
collection PubMed
description BACKGROUND: In patients with cancers of the pancreatic and biliary tract quality of life (QOL) improvement is the main treatment goal, since survival can be prolonged only marginally. Up to date, knowledge on QOL impairments throughout the entire treatment process, often including several chemotherapy lines, is scarce. Our study aimed at investigating QOL trajectories from adjuvant treatment to palliative 3(rd)-line therapy METHODS: Patients were included in routine electronic patient-reported outcome monitoring at Kufstein County Hospital at the time of diagnosis and assessed with the EORTC QLQ-C30 during each chemotherapy cycle. RESULTS: Eighty out of 147 patients with pancreatic cancer or cancer of the bile ducts treated at the Kufstein County Hospital, fulfilled inclusion criteria and could be included in the study (mean age 67.4 years; 53.8% women). Physical, Emotional and Cognitive Functioning, and Global QOL deteriorated across chemotherapy lines, whereas Fatigue, Pain, Dyspnoea, Sleeping Disturbances, Diarrhoea, and Taste Alterations increased. With regard to Physical Functioning, Global QOL, Fatigue, Dyspnoea, Diarrhoea and Taste Alterations, the patients receiving adjuvant or 1(st)-line palliative chemotherapy did not differ significantly. Most patients in 2(nd)- or 3(rd)-line chemotherapy showed significantly higher impairments and symptom burden. However, patients under 1(st) and 2(nd)-line treatment showed stable QOL trajectories, whereas 3(rd)-line patients perceived substantial deteriorations. CONCLUSIONS: The results suggest early palliative treatment initiation to stabilise QOL on a level as high as possible. The continuous QOL improvement during adjuvant treatment, probably reflecting post-operative recovery, may indicate that deleterious effects of adjuvant chemotherapy on QOL are highly unlikely.
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spelling pubmed-34885262012-11-05 Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract Zabernigg, August Giesinger, Johannes M Pall, Georg Gamper, Eva-Maria Gattringer, Klaus Wintner, Lisa M Sztankay, Monika J Holzner, Bernhard BMC Cancer Research Article BACKGROUND: In patients with cancers of the pancreatic and biliary tract quality of life (QOL) improvement is the main treatment goal, since survival can be prolonged only marginally. Up to date, knowledge on QOL impairments throughout the entire treatment process, often including several chemotherapy lines, is scarce. Our study aimed at investigating QOL trajectories from adjuvant treatment to palliative 3(rd)-line therapy METHODS: Patients were included in routine electronic patient-reported outcome monitoring at Kufstein County Hospital at the time of diagnosis and assessed with the EORTC QLQ-C30 during each chemotherapy cycle. RESULTS: Eighty out of 147 patients with pancreatic cancer or cancer of the bile ducts treated at the Kufstein County Hospital, fulfilled inclusion criteria and could be included in the study (mean age 67.4 years; 53.8% women). Physical, Emotional and Cognitive Functioning, and Global QOL deteriorated across chemotherapy lines, whereas Fatigue, Pain, Dyspnoea, Sleeping Disturbances, Diarrhoea, and Taste Alterations increased. With regard to Physical Functioning, Global QOL, Fatigue, Dyspnoea, Diarrhoea and Taste Alterations, the patients receiving adjuvant or 1(st)-line palliative chemotherapy did not differ significantly. Most patients in 2(nd)- or 3(rd)-line chemotherapy showed significantly higher impairments and symptom burden. However, patients under 1(st) and 2(nd)-line treatment showed stable QOL trajectories, whereas 3(rd)-line patients perceived substantial deteriorations. CONCLUSIONS: The results suggest early palliative treatment initiation to stabilise QOL on a level as high as possible. The continuous QOL improvement during adjuvant treatment, probably reflecting post-operative recovery, may indicate that deleterious effects of adjuvant chemotherapy on QOL are highly unlikely. BioMed Central 2012-09-06 /pmc/articles/PMC3488526/ /pubmed/22950826 http://dx.doi.org/10.1186/1471-2407-12-390 Text en Copyright ©2012 Zabernigg et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zabernigg, August
Giesinger, Johannes M
Pall, Georg
Gamper, Eva-Maria
Gattringer, Klaus
Wintner, Lisa M
Sztankay, Monika J
Holzner, Bernhard
Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
title Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
title_full Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
title_fullStr Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
title_full_unstemmed Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
title_short Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
title_sort quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488526/
https://www.ncbi.nlm.nih.gov/pubmed/22950826
http://dx.doi.org/10.1186/1471-2407-12-390
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