LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival

BACKGROUND: We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we q...

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Detalles Bibliográficos
Autores principales: Kuhlmann, Jan Dominik, Schwarzenbach, Heidi, Wimberger, Pauline, Poetsch, Micaela, Kimmig, Rainer, Kasimir-Bauer, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488536/
https://www.ncbi.nlm.nih.gov/pubmed/22849543
http://dx.doi.org/10.1186/1471-2407-12-325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488536/
https://www.ncbi.nlm.nih.gov/pubmed/22849543
http://dx.doi.org/10.1186/1471-2407-12-325

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