Cargando…

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a devastating neurodegenerative disorder characterized by progressive motor debilitation, which affects several million people worldwide. Recent evidence suggests that glial cell activation and its inflammatory response may contribute to the progressive degene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghosh, Anamitra, Kanthasamy, Arthi, Joseph, Joy, Anantharam, Vellareddy, Srivastava, Pallavi, Dranka, Brian P, Kalyanaraman, Balaraman, Kanthasamy, Anumantha G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488558/ https://www.ncbi.nlm.nih.gov/pubmed/23092448 http://dx.doi.org/10.1186/1742-2094-9-241

Ejemplares similares

Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson’s Disease
por: Saminathan, Hariharan, et al.
Publicado: (2021)

Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival during 6-OHDA-Induced Oxidative Stress
por: Asaithambi, Arunkumar, et al.
Publicado: (2014)

Neuroprotective Effect of Resveratrol Against Methamphetamine-Induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity
por: Kanthasamy, Kavin, et al.
Publicado: (2011)

Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease
por: Kanthasamy, Anumantha G, et al.
Publicado: (2008)

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation
por: Gordon, Richard, et al.
Publicado: (2012)

Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration
por: Asaithambi, Arunkumar, et al.
Publicado: (2011)

N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells
por: Chandramani Shivalingappa, Prashanth, et al.
Publicado: (2012)

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation
por: Sun, Faneng, et al.
Publicado: (2008)

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation
por: Harischandra, Dilshan S., et al.
Publicado: (2019)

Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation
por: Huang, Minhong, et al.
Publicado: (2023)

Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease
por: Huang, Minhong, et al.
Publicado: (2022)

Mitochondrial dysfunction–induced H3K27 hyperacetylation perturbs enhancers in Parkinson’s disease
por: Huang, Minhong, et al.
Publicado: (2021)

Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases
por: Kondru, Naveen, et al.
Publicado: (2017)

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders
por: Padhi, Piyush, et al.
Publicado: (2022)

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease
por: Samidurai, Manikandan, et al.
Publicado: (2020)

Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease
por: Panicker, Nikhil, et al.
Publicado: (2019)

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
por: Sarkar, Souvarish, et al.
Publicado: (2017)

An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development
por: Kondru, Naveen, et al.
Publicado: (2020)

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway
por: Samidurai, Manikandan, et al.
Publicado: (2021)

Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study
por: Ghaisas, Shivani, et al.
Publicado: (2021)

Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology
por: Malovic, Emir, et al.
Publicado: (2021)

Acute hydrogen sulfide–induced neuropathology and neurological sequelae: challenges for translational neuroprotective research
por: Rumbeiha, Wilson, et al.
Publicado: (2016)

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
por: Gordon, Richard, et al.
Publicado: (2016)

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
por: Panicker, Nikhil, et al.
Publicado: (2019)

Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease
por: Xu, Qi, et al.
Publicado: (2016)

Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression
por: Schlichtmann, Benjamin W., et al.
Publicado: (2023)

Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model
por: Xu, Qi, et al.
Publicado: (2011)

EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model
por: Chen, Dan, et al.
Publicado: (2015)

Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity
por: Yen, Chi-Fu, et al.
Publicado: (2016)

New protocol for kinetic assay seeding ability recovery “KASAR” from formalin-fixed paraffin-embedded tissues
por: Hepker, Monica, et al.
Publicado: (2023)

Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models
por: Sharma, Shaunik, et al.
Publicado: (2018)

Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease
por: Kalyanaraman, Balaraman
Publicado: (2020)

Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury
por: Harper, Matthew M., et al.
Publicado: (2020)

Improvement of Pharmacokinetics Behavior of Apocynin by Nitrone Derivatization: Comparative Pharmacokinetics of Nitrone-Apocynin and its Parent Apocynin in Rats
por: Wang, Kaiyu, et al.
Publicado: (2013)

Apocynin: Molecular Aptitudes
por: Stefanska, J., et al.
Publicado: (2008)

Multisystem Inflammatory Syndrome in Children Presenting as Subacute Intestinal Obstruction
por: Joghee, Sunil, et al.
Publicado: (2021)

Apocynin, a Low Molecular Oral Treatment for Neurodegenerative Disease
por: ‘t Hart, Bert A., et al.
Publicado: (2014)

Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism
por: Vinithakumari, Akhil A., et al.
Publicado: (2022)

Characterization of Astrocytic Response after Experiencing Cavitation In Vitro
por: Wrede, Alex H., et al.
Publicado: (2020)

Characterization of Astrocytic Response after Experiencing Cavitation In Vitro (Global Challenges 7/2020)
por: Wrede, Alex H., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cj46pdo7pmfl9631vopojnrbit