Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

BACKGROUND: Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene p53. Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of re...

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Detalles Bibliográficos
Autores principales: Yoshida, Go J, Fuchimoto, Yasushi, Osumi, Tomoo, Shimada, Hiroyuki, Hosaka, Seiichi, Morioka, Hideo, Mukai, Makio, Masugi, Yohei, Sakamoto, Michiie, Kuroda, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488581/
https://www.ncbi.nlm.nih.gov/pubmed/23031740
http://dx.doi.org/10.1186/1471-2407-12-444

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