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Virtual screening of ABCC1 transporter nucleotidebinding domains as a therapeutic target in multidrug resistant cancer

ABCC1 is a member of the ATP-binding Cassette super family of transporters, actively effluxes xenobiotics from cells. Clinically, ABCC1 expression is linked to cancer multidrug resistance. Substrate efflux is energised by ATP binding and hydrolysis at the nucleotide-binding domains (NBDs) and inhibi...

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Detalles Bibliográficos
Autores principales:	Rungsardthong, Kanin, Mares- Sámano, Sergio, Penny, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2012
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488831/ https://www.ncbi.nlm.nih.gov/pubmed/23144549 http://dx.doi.org/10.6026/97320630008907

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