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Novel germline CDK4 mutations in patients with head and neck cancer

BACKGROUND: Cyclin-dependent kinase 4 (CDK4) together with its regulatory subunit cyclin D1, governs cell cycle progression through G(1) phase. Cyclin-dependent kinase inhibitors, including p16(INK4A) in turn regulate CDK4. In particular, deregulation of the p16/CDK4/cyclin D1 complex has been estab...

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Detalles Bibliográficos
Autores principales:	Sabir, Maimoona, Baig, Ruqia Mehmood, Mahjabeen, Ishrat, Kayani, Mahmood Akhtar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488972/ https://www.ncbi.nlm.nih.gov/pubmed/22932448 http://dx.doi.org/10.1186/1897-4287-10-11

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