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Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore

BACKGROUND: The inhalation anesthetic isoflurane has been shown to open the mitochondrial permeability transition pore (mPTP) and induce caspase activation and apoptosis, which may lead to learning and memory impairment. Cyclosporine A, a blocker of mPTP opening might attenuate the isoflurane-induce...

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Detalles Bibliográficos
Autores principales:	Zhang, Yiying, Dong, Yuanlin, Xu, Zhipeng, Xie, Zhongcong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489514/ https://www.ncbi.nlm.nih.gov/pubmed/22901676 http://dx.doi.org/10.1186/2045-9912-2-20

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