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Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes

BACKGROUND: Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied as a therapeutic agent for this tumour type. However, little is known on the do...

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Detalles Bibliográficos
Autores principales:	Klopfleisch, Robert, Meyer, Anja, Schlieben, Patricia, Bondzio, Angelika, Weise, Chris, Lenze, Dido, Hummel, Michael, Einspanier, Ralf, Gruber, Achim D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489685/ https://www.ncbi.nlm.nih.gov/pubmed/22747577 http://dx.doi.org/10.1186/1746-6148-8-96

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