Cargando…

Spatiotemporal and Functional Characterisation of the Plasmodium falciparum cGMP-Dependent Protein Kinase

Signalling by 3′–5′-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of the life cycle. The Plasmodium falciparum isoform...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hopp, Christine S., Flueck, Christian, Solyakov, Lev, Tobin, Andrew, Baker, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489689/ https://www.ncbi.nlm.nih.gov/pubmed/23139764 http://dx.doi.org/10.1371/journal.pone.0048206

Ejemplares similares

Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress
por: Kim, Jeong Joo, et al.
Publicado: (2015)

The role of cGMP signalling in regulating life cycle progression of Plasmodium
por: Hopp, Christine S., et al.
Publicado: (2012)

Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
por: Rotella, David, et al.
Publicado: (2021)

Crystal structures of the carboxyl cGMP binding domain of plasmodium falciparum cGMP-dependent protein kinase reveals a novel salt bridge crucial for activation
por: Kim, Jeong Joo, et al.
Publicado: (2013)

Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress
por: Nofal, Stephanie D., et al.
Publicado: (2021)

The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase
por: Franz, Eugen, et al.
Publicado: (2015)

Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis
por: Schinner, Elisabeth, et al.
Publicado: (2017)

Construction of novel cGMP FRET-sensors based on PKG from Plasmodium falciparum
por: Calamera, Gaia, et al.
Publicado: (2015)

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase
por: McRobert, Louisa, et al.
Publicado: (2008)

The role of the cGMP-dependent protein kinase in development of the malaria parasite
por: McRobert, Louisa, et al.
Publicado: (2009)

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
por: Penzo, Maria, et al.
Publicado: (2019)

Development of a Transgenic Plasmodium berghei Line (Pb(pfpkg)) Expressing the P. falciparum cGMP-Dependent Protein Kinase, a Novel Antimalarial Drug Target
por: Tewari, Rita, et al.
Publicado: (2014)

cGMP-Dependent Protein Kinase Inhibitors in Health and Disease
por: Wolfertstetter, Stefanie, et al.
Publicado: (2013)

Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity
por: Miyashita, Kazutoshi, et al.
Publicado: (2009)

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
por: El Bakkouri, Majida, et al.
Publicado: (2019)

The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts Angiotensin II-stimulated calcium mobilization in cardiac myocytes
por: Klaiber, Michael, et al.
Publicado: (2009)

cGMP kinase: past, presence and future
por: Hofmann, Franz, et al.
Publicado: (2013)

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs
por: Baker, David A., et al.
Publicado: (2020)

Suppression of kidney fibrosis by cGMP-dependent protein kinase I
por: Schinner, Elisabeth, et al.
Publicado: (2011)

Activation profile of cGMP-dependent protein kinase Iα
por: Wolter, Sabine, et al.
Publicado: (2013)

Suppression of kidney fibrosis by cGMP-dependent protein kinase I
por: Schinner, Elisabeth, et al.
Publicado: (2013)

Transient kinetics of a cGMP-dependent cGMP-specific phosphodiesterase from Dictyostelium discoideum
Publicado: (1984)

Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design
por: Huang, Gilbert Y., et al.
Publicado: (2014)

NO-dependent cGMP signalling in neurons and astrocytes
por: Giesen, Jan, et al.
Publicado: (2015)

cGMP kinase I regulates glucagon release
por: Leiss, Veronika, et al.
Publicado: (2009)

cGMP-Dependent Protein Kinase I Is Crucial for Angiogenesis and Postnatal Vasculogenesis
por: Aicher, Alexandra, et al.
Publicado: (2009)

cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation
por: Bucci, Mariarosaria, et al.
Publicado: (2012)

cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses
por: Gross, Owen P., et al.
Publicado: (2015)

Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases
por: Subramanian, Hariharan, et al.
Publicado: (2013)

Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits
por: Averaimo, Stefania, et al.
Publicado: (2014)

NO/cGMP signalling in platelets
por: Schinner, Elisabeth, et al.
Publicado: (2009)

cGMP and cardiac hypertrophy
por: Perera, Ruwan K, et al.
Publicado: (2015)

Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase, alterations in hyperammonemia
por: Monfort, Pilar, et al.
Publicado: (2005)

Rescue of cGMP kinase I and the cause of premature death
por: Hofmann, Franz, et al.
Publicado: (2009)

cGMP kinase I, cardiac hypertrophy and PDE inhibition
por: Patrucco, Enrico, et al.
Publicado: (2011)

Regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase
por: Zhang, Tong, et al.
Publicado: (2009)

Role of cGMP-dependent protein kinases for fear memory formation in the lateral amygdala
por: Paul, Cindy, et al.
Publicado: (2009)

Function of cGMP-dependent protein kinase II in volume expansion-induced diuresis
por: Schramm, Andrea, et al.
Publicado: (2013)

Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system
por: Prysyazhna, Oleksandra, et al.
Publicado: (2015)

Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II
por: Campbell, James C, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gs2d5f3idslm6fl79oe2g0t4uc