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Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

BACKGROUND: Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefor...

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Detalles Bibliográficos
Autores principales:	Shim, Byoung-Shik, Stadler, Konrad, Nguyen, Huan Huu, Yun, Cheol-Heui, Kim, Dong Wook, Chang, Jun, Czerkinsky, Cecil, Song, Man Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489719/ https://www.ncbi.nlm.nih.gov/pubmed/22995185 http://dx.doi.org/10.1186/1743-422X-9-215

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