Distinct anti-tumoral functions of adaptive immune cells in liver cancer

Hepatocellular carcinoma (HCC) commonly arises in chronically inflamed livers, but may also provoke (anti-tumoral) immune responses. Using non-inflammatory diethylnitrosamine (DEN)-induced liver cancer in mice, we demonstrate that distinct axes of the adaptive immune system, which are also prognosti...

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Detalles Bibliográficos
Autores principales: Schneider, Carlo, Tacke, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489751/
https://www.ncbi.nlm.nih.gov/pubmed/23162763
http://dx.doi.org/10.4161/onci.20304
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author Schneider, Carlo
Tacke, Frank
author_facet Schneider, Carlo
Tacke, Frank
author_sort Schneider, Carlo
collection PubMed
description Hepatocellular carcinoma (HCC) commonly arises in chronically inflamed livers, but may also provoke (anti-tumoral) immune responses. Using non-inflammatory diethylnitrosamine (DEN)-induced liver cancer in mice, we demonstrate that distinct axes of the adaptive immune system, which are also prognostic in human HCC, actively suppress hepatocarcinogenesis by controlling tumor formation and progression.
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spelling pubmed-34897512012-11-16 Distinct anti-tumoral functions of adaptive immune cells in liver cancer Schneider, Carlo Tacke, Frank Oncoimmunology Author's View Hepatocellular carcinoma (HCC) commonly arises in chronically inflamed livers, but may also provoke (anti-tumoral) immune responses. Using non-inflammatory diethylnitrosamine (DEN)-induced liver cancer in mice, we demonstrate that distinct axes of the adaptive immune system, which are also prognostic in human HCC, actively suppress hepatocarcinogenesis by controlling tumor formation and progression. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489751/ /pubmed/23162763 http://dx.doi.org/10.4161/onci.20304 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Schneider, Carlo
Tacke, Frank
Distinct anti-tumoral functions of adaptive immune cells in liver cancer
title Distinct anti-tumoral functions of adaptive immune cells in liver cancer
title_full Distinct anti-tumoral functions of adaptive immune cells in liver cancer
title_fullStr Distinct anti-tumoral functions of adaptive immune cells in liver cancer
title_full_unstemmed Distinct anti-tumoral functions of adaptive immune cells in liver cancer
title_short Distinct anti-tumoral functions of adaptive immune cells in liver cancer
title_sort distinct anti-tumoral functions of adaptive immune cells in liver cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489751/
https://www.ncbi.nlm.nih.gov/pubmed/23162763
http://dx.doi.org/10.4161/onci.20304
work_keys_str_mv AT schneidercarlo distinctantitumoralfunctionsofadaptiveimmunecellsinlivercancer
AT tackefrank distinctantitumoralfunctionsofadaptiveimmunecellsinlivercancer

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