Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma

To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mengxian, Lahn, Michael, Huber, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489753/
https://www.ncbi.nlm.nih.gov/pubmed/23162765
http://dx.doi.org/10.4161/onci.19789
_version_ 1782248775260045312
author Zhang, Mengxian
Lahn, Michael
Huber, Peter E.
author_facet Zhang, Mengxian
Lahn, Michael
Huber, Peter E.
author_sort Zhang, Mengxian
collection PubMed
description To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition and angiogenesis.1
format Online
Article
Text
id pubmed-3489753
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-34897532012-11-16 Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma Zhang, Mengxian Lahn, Michael Huber, Peter E. Oncoimmunology Author's View To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able to potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition and angiogenesis.1 Landes Bioscience 2012-09-01 /pmc/articles/PMC3489753/ /pubmed/23162765 http://dx.doi.org/10.4161/onci.19789 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Zhang, Mengxian
Lahn, Michael
Huber, Peter E.
Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
title Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
title_full Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
title_fullStr Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
title_full_unstemmed Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
title_short Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
title_sort translating the combination of tgfβ blockade and radiotherapy into clinical development in glioblastoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489753/
https://www.ncbi.nlm.nih.gov/pubmed/23162765
http://dx.doi.org/10.4161/onci.19789
work_keys_str_mv AT zhangmengxian translatingthecombinationoftgfbblockadeandradiotherapyintoclinicaldevelopmentinglioblastoma
AT lahnmichael translatingthecombinationoftgfbblockadeandradiotherapyintoclinicaldevelopmentinglioblastoma
AT huberpetere translatingthecombinationoftgfbblockadeandradiotherapyintoclinicaldevelopmentinglioblastoma

Ejemplares similares