New insights on the role of CD8(+)CD57(+) T-cells in cancer

Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Richard C., Hwu, Patrick, Radvanyi, Laszlo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489757/
https://www.ncbi.nlm.nih.gov/pubmed/23162769
http://dx.doi.org/10.4161/onci.20307
Descripción
Sumario:Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs.

Ejemplares similares