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New insights on the role of CD8(+)CD57(+) T-cells in cancer
Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489757/ https://www.ncbi.nlm.nih.gov/pubmed/23162769 http://dx.doi.org/10.4161/onci.20307 |
| _version_ | 1782248776176500736 |
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| author | Wu, Richard C. Hwu, Patrick Radvanyi, Laszlo G. |
| author_facet | Wu, Richard C. Hwu, Patrick Radvanyi, Laszlo G. |
| author_sort | Wu, Richard C. |
| collection | PubMed |
| description | Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs. |
| format | Online Article Text |
| id | pubmed-3489757 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34897572012-11-16 New insights on the role of CD8(+)CD57(+) T-cells in cancer Wu, Richard C. Hwu, Patrick Radvanyi, Laszlo G. Oncoimmunology Author's View Incomplete differentiation of CD8+ cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8+CD57+ T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489757/ /pubmed/23162769 http://dx.doi.org/10.4161/onci.20307 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Wu, Richard C. Hwu, Patrick Radvanyi, Laszlo G. New insights on the role of CD8(+)CD57(+) T-cells in cancer |
| title | New insights on the role of CD8(+)CD57(+) T-cells in cancer |
| title_full | New insights on the role of CD8(+)CD57(+) T-cells in cancer |
| title_fullStr | New insights on the role of CD8(+)CD57(+) T-cells in cancer |
| title_full_unstemmed | New insights on the role of CD8(+)CD57(+) T-cells in cancer |
| title_short | New insights on the role of CD8(+)CD57(+) T-cells in cancer |
| title_sort | new insights on the role of cd8(+)cd57(+) t-cells in cancer |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489757/ https://www.ncbi.nlm.nih.gov/pubmed/23162769 http://dx.doi.org/10.4161/onci.20307 |
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