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Monoclonal antibody (mAb)-based cancer therapy: Is it time to reevaluate dosing strategies?

Compelling evidence indicates Type I CD20 immunotherapeutic mAbs promote targeted tumor cell elimination exclusively via immune effector functions, which can be exhausted/saturated. mAb dosing paradigms should therefore take into account the capacity of these cytotoxic mechanisms, leading to the con...

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Detalles Bibliográficos
Autores principales:	Lindorfer, Margaret A., Wiestner, Adrian, Zent, Clive S., Taylor, Ronald P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489759/ https://www.ncbi.nlm.nih.gov/pubmed/23162771 http://dx.doi.org/10.4161/onci.20368

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