DNA methylation markers for breast cancer prognosis: Unmasking the immune component

Currently, most of the prognostic and predictive gene expression signatures emerging for breast cancer concern the tumor component. In Dedeurwaerder et al. we show that DNA methylation profiling of breast tumors is a particularly sensitive means of capturing features of the immune component of breas...

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Detalles Bibliográficos
Autores principales: Dedeurwaerder, Sarah, Fuks, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489760/
https://www.ncbi.nlm.nih.gov/pubmed/23162772
http://dx.doi.org/10.4161/onci.19996
Descripción
Sumario:Currently, most of the prognostic and predictive gene expression signatures emerging for breast cancer concern the tumor component. In Dedeurwaerder et al. we show that DNA methylation profiling of breast tumors is a particularly sensitive means of capturing features of the immune component of breast tumors. Most importantly, correlation is observed between T-cell marker genes and breast cancer clinical outcome.

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