The role of SMAC mimetics in regulation of tumor cell death and immunity

Mimetics of second mitochondria-derived activator of caspases (SMAC) enhance tumor cell death in a variety of cancers. Several molecular mechanisms of action have been identified. However, it was only recently that the modus of action was linked to stimulation of anti-tumor immunity. Here we comment...

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Detalles Bibliográficos
Autores principales: Emeagi, Perpetua U., Thielemans, Kris, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489761/
https://www.ncbi.nlm.nih.gov/pubmed/23162773
http://dx.doi.org/10.4161/onci.20369
Descripción
Sumario:Mimetics of second mitochondria-derived activator of caspases (SMAC) enhance tumor cell death in a variety of cancers. Several molecular mechanisms of action have been identified. However, it was only recently that the modus of action was linked to stimulation of anti-tumor immunity. Here we comment on these findings, highlighting several remaining questions.

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