The role of SMAC mimetics in regulation of tumor cell death and immunity

Mimetics of second mitochondria-derived activator of caspases (SMAC) enhance tumor cell death in a variety of cancers. Several molecular mechanisms of action have been identified. However, it was only recently that the modus of action was linked to stimulation of anti-tumor immunity. Here we comment...

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Autores principales: Emeagi, Perpetua U., Thielemans, Kris, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489761/
https://www.ncbi.nlm.nih.gov/pubmed/23162773
http://dx.doi.org/10.4161/onci.20369
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author Emeagi, Perpetua U.
Thielemans, Kris
Breckpot, Karine
author_facet Emeagi, Perpetua U.
Thielemans, Kris
Breckpot, Karine
author_sort Emeagi, Perpetua U.
collection PubMed
description Mimetics of second mitochondria-derived activator of caspases (SMAC) enhance tumor cell death in a variety of cancers. Several molecular mechanisms of action have been identified. However, it was only recently that the modus of action was linked to stimulation of anti-tumor immunity. Here we comment on these findings, highlighting several remaining questions.
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spelling pubmed-34897612012-11-16 The role of SMAC mimetics in regulation of tumor cell death and immunity Emeagi, Perpetua U. Thielemans, Kris Breckpot, Karine Oncoimmunology Author's View Mimetics of second mitochondria-derived activator of caspases (SMAC) enhance tumor cell death in a variety of cancers. Several molecular mechanisms of action have been identified. However, it was only recently that the modus of action was linked to stimulation of anti-tumor immunity. Here we comment on these findings, highlighting several remaining questions. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489761/ /pubmed/23162773 http://dx.doi.org/10.4161/onci.20369 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Emeagi, Perpetua U.
Thielemans, Kris
Breckpot, Karine
The role of SMAC mimetics in regulation of tumor cell death and immunity
title The role of SMAC mimetics in regulation of tumor cell death and immunity
title_full The role of SMAC mimetics in regulation of tumor cell death and immunity
title_fullStr The role of SMAC mimetics in regulation of tumor cell death and immunity
title_full_unstemmed The role of SMAC mimetics in regulation of tumor cell death and immunity
title_short The role of SMAC mimetics in regulation of tumor cell death and immunity
title_sort role of smac mimetics in regulation of tumor cell death and immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489761/
https://www.ncbi.nlm.nih.gov/pubmed/23162773
http://dx.doi.org/10.4161/onci.20369
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