Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles

Current ovarian cancer treatments based on surgery/chemotherapy show limited efficacy. Targeting immunosuppression is a requirement for the effectiveness of novel promising anti-tumor immunotherapies. Our latest work in preclinical models shows that nanoparticle-mediated delivery of immunostimulator...

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Detalles Bibliográficos
Autores principales: Cubillos-Ruiz, Juan R., Sempere, Lorenzo F., Conejo-Garcia, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489762/
https://www.ncbi.nlm.nih.gov/pubmed/23162774
http://dx.doi.org/10.4161/onci.20020
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author Cubillos-Ruiz, Juan R.
Sempere, Lorenzo F.
Conejo-Garcia, Jose R.
author_facet Cubillos-Ruiz, Juan R.
Sempere, Lorenzo F.
Conejo-Garcia, Jose R.
author_sort Cubillos-Ruiz, Juan R.
collection PubMed
description Current ovarian cancer treatments based on surgery/chemotherapy show limited efficacy. Targeting immunosuppression is a requirement for the effectiveness of novel promising anti-tumor immunotherapies. Our latest work in preclinical models shows that nanoparticle-mediated delivery of immunostimulatory microRNAs specifically to tumor-associated leukocytes is sufficient to re-program immunological control of metastatic ovarian cancers.
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spelling pubmed-34897622012-11-16 Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles Cubillos-Ruiz, Juan R. Sempere, Lorenzo F. Conejo-Garcia, Jose R. Oncoimmunology Author's View Current ovarian cancer treatments based on surgery/chemotherapy show limited efficacy. Targeting immunosuppression is a requirement for the effectiveness of novel promising anti-tumor immunotherapies. Our latest work in preclinical models shows that nanoparticle-mediated delivery of immunostimulatory microRNAs specifically to tumor-associated leukocytes is sufficient to re-program immunological control of metastatic ovarian cancers. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489762/ /pubmed/23162774 http://dx.doi.org/10.4161/onci.20020 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Cubillos-Ruiz, Juan R.
Sempere, Lorenzo F.
Conejo-Garcia, Jose R.
Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles
title Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles
title_full Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles
title_fullStr Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles
title_full_unstemmed Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles
title_short Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles
title_sort good things come in small packages: therapeutic anti-tumor immunity induced by microrna nanoparticles
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489762/
https://www.ncbi.nlm.nih.gov/pubmed/23162774
http://dx.doi.org/10.4161/onci.20020
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