Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs

It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release o...

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Autores principales: Yi, Yongxiang, Zhou, Zhenxian, Shu, Su, Fang, Yuan, Twitty, Chris, Hilton, Traci L., Aung, Sandra, Urba, Walter J., Fox, Bernard A., Hu, Hong-Ming, Li, Yuhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489765/
https://www.ncbi.nlm.nih.gov/pubmed/23162777
http://dx.doi.org/10.4161/onci.20059
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author Yi, Yongxiang
Zhou, Zhenxian
Shu, Su
Fang, Yuan
Twitty, Chris
Hilton, Traci L.
Aung, Sandra
Urba, Walter J.
Fox, Bernard A.
Hu, Hong-Ming
Li, Yuhuan
author_facet Yi, Yongxiang
Zhou, Zhenxian
Shu, Su
Fang, Yuan
Twitty, Chris
Hilton, Traci L.
Aung, Sandra
Urba, Walter J.
Fox, Bernard A.
Hu, Hong-Ming
Li, Yuhuan
author_sort Yi, Yongxiang
collection PubMed
description It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.
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spelling pubmed-34897652012-11-16 Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs Yi, Yongxiang Zhou, Zhenxian Shu, Su Fang, Yuan Twitty, Chris Hilton, Traci L. Aung, Sandra Urba, Walter J. Fox, Bernard A. Hu, Hong-Ming Li, Yuhuan Oncoimmunology Author's View It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489765/ /pubmed/23162777 http://dx.doi.org/10.4161/onci.20059 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Yi, Yongxiang
Zhou, Zhenxian
Shu, Su
Fang, Yuan
Twitty, Chris
Hilton, Traci L.
Aung, Sandra
Urba, Walter J.
Fox, Bernard A.
Hu, Hong-Ming
Li, Yuhuan
Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs
title Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs
title_full Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs
title_fullStr Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs
title_full_unstemmed Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs
title_short Autophagy-assisted antigen cross-presentation: Autophagosome as the argo of shared tumor-specific antigens and DAMPs
title_sort autophagy-assisted antigen cross-presentation: autophagosome as the argo of shared tumor-specific antigens and damps
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489765/
https://www.ncbi.nlm.nih.gov/pubmed/23162777
http://dx.doi.org/10.4161/onci.20059
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